000007604 001__ 7604
000007604 005__ 20231129124935.0
000007604 0247_ $$2DOI$$a10.6083/m4222sw2
000007604 037__ $$aETD
000007604 245__ $$aThe cytokine-induced sickness response: investigations of how the central nervous system controls the biological response to disease
000007604 260__ $$bOregon Health and Science University
000007604 269__ $$a2017
000007604 336__ $$aDissertation
000007604 502__ $$bPh.D.
000007604 520__ $$aDisease is an ever-present threat to the survival of the individual. To meet these challenges, higher organisms have developed complex mechanisms designed to heal and fight for survival. These mechanisms manifest as physiologic and behavioral alterations including fever, anorexia, malaise and loss of body weight (collectively the sickness response). Previous research has demonstrated that these effects are mediated by cytokine signaling. Our lab has contributed to this body of knowledge by showing that inflammatory cytokines directly modulate the activity of the central melanocortin and orexin signaling systems. However, much remains unknown about the role of central nervous system inflammation and how cytokine signaling is transmitted from the periphery to the central nervous system. The data presented in this thesis contribute to the understanding of how cytokines act to stimulate physiologic and behavioral modifications that promote survival and healing. The novel implication that fenestrated capillary-specific signaling mechanisms are responsible for these behaviors represents a new potential for therapeutic interventions.
000007604 542__ $$fIn copyright - single owner
000007604 650__ $$aBehavior$$015411
000007604 650__ $$aCytokines$$028964
000007604 650__ $$aHypothalamus$$020595
000007604 650__ $$aInflammation$$020800
000007604 691__ $$aSchool of Medicine$$041369
000007604 692__ $$aVollum Institute$$041509
000007604 7001_ $$aKnoll, J. Gabriel
000007604 8564_ $$9aa1c5969-0965-4593-8317-2ce4be3e2571$$s19567187$$uhttps://digitalcollections.ohsu.edu/record/7604/files/Knoll.J.2017.pdf
000007604 905__ $$a/rest/prod/c8/21/gk/28/c821gk28w
000007604 909CO $$ooai:digitalcollections.ohsu.edu:7604$$pstudent-work
000007604 980__ $$aTheses and Dissertations