TY  - GEN
N2  - The transcription factor MYC has been studied for decades as one of the most potent cancer drivers. Recent advances in next generation sequencing and molecular biology have uncovered a broad impact of MYC and its partners on the genome under both physiological and cancerous settings. This thesis investigates the interaction between MYC and PIN1, a previously identified regulator of MYC, with focus on the biophysical features, subnuclear localization, as well as the functional consequences. Such understanding potentiates more clinical utility of MYC by providing new biomarkers of MYC activity and novel strategies to inhibit MYC oncogenic functions.
DO  - 10.6083/m43j3chp
DO  - DOI
AB  - The transcription factor MYC has been studied for decades as one of the most potent cancer drivers. Recent advances in next generation sequencing and molecular biology have uncovered a broad impact of MYC and its partners on the genome under both physiological and cancerous settings. This thesis investigates the interaction between MYC and PIN1, a previously identified regulator of MYC, with focus on the biophysical features, subnuclear localization, as well as the functional consequences. Such understanding potentiates more clinical utility of MYC by providing new biomarkers of MYC activity and novel strategies to inhibit MYC oncogenic functions.
T1  - Mechanistic insight into PIN1 regulation on MYC: A new interaction pattern & the association with the nuclear pore
DA  - 2017
AU  - Su, Yulong
L1  - https://digitalcollections.ohsu.edu/record/7607/files/Su.Yulong.2017.pdf
PB  - Oregon Health and Science University
PY  - 2017
ID  - 7607
L4  - https://digitalcollections.ohsu.edu/record/7607/files/Su.Yulong.2017.pdf
KW  - Nuclear Pore
KW  - Chromatin
KW  - Transcription Factors
KW  - posttranslational modifications
TI  - Mechanistic insight into PIN1 regulation on MYC: A new interaction pattern & the association with the nuclear pore
Y1  - 2017
L2  - https://digitalcollections.ohsu.edu/record/7607/files/Su.Yulong.2017.pdf
LK  - https://digitalcollections.ohsu.edu/record/7607/files/Su.Yulong.2017.pdf
UR  - https://digitalcollections.ohsu.edu/record/7607/files/Su.Yulong.2017.pdf
ER  -