000007607 001__ 7607
000007607 005__ 20240124114247.0
000007607 0247_ $$2DOI$$a10.6083/m43j3chp
000007607 037__ $$aETD
000007607 245__ $$aMechanistic insight into PIN1 regulation on MYC: A new interaction pattern & the association with the nuclear pore
000007607 260__ $$bOregon Health and Science University
000007607 269__ $$a2017
000007607 336__ $$aDissertation
000007607 502__ $$bPh.D.
000007607 520__ $$aThe transcription factor MYC has been studied for decades as one of the most potent cancer drivers. Recent advances in next generation sequencing and molecular biology have uncovered a broad impact of MYC and its partners on the genome under both physiological and cancerous settings. This thesis investigates the interaction between MYC and PIN1, a previously identified regulator of MYC, with focus on the biophysical features, subnuclear localization, as well as the functional consequences. Such understanding potentiates more clinical utility of MYC by providing new biomarkers of MYC activity and novel strategies to inhibit MYC oncogenic functions.
000007607 542__ $$fIn copyright - single owner
000007607 650__ $$aNuclear Pore$$032925
000007607 650__ $$aChromatin$$016651
000007607 650__ $$aTranscription Factors$$027255
000007607 6531_ $$aposttranslational modifications
000007607 691__ $$aSchool of Medicine$$041369
000007607 692__ $$aDepartment of Molecular and Medical Genetics$$041428
000007607 7001_ $$aSu, Yulong
000007607 8564_ $$959988c73-e4cb-4e54-bcdd-8f11c62b3a47$$s19201622$$uhttps://digitalcollections.ohsu.edu/record/7607/files/Su.Yulong.2017.pdf
000007607 905__ $$a/rest/prod/9z/90/30/46/9z9030469
000007607 909CO $$ooai:digitalcollections.ohsu.edu:7607$$pstudent-work
000007607 980__ $$aTheses and Dissertations