TY  - GEN
N2  - This dissertation explores the importance of understanding the genetic mechanisms that lead to cancer. Specifically, in Chapter 2 succinate dehydrogenase subunit A variants of unknown significance are categorized based on how they affect succinate dehydrogenase complex function and therefore whether or not they predispose patients to succinate dehydrogenase-deficient cancer. Chapter 3 works to identify novel mechanisms of succinate dehydrogenase-deficiency in tumors with an unknown molecular classification. Finally, Chapter 4 reviews the genetic landscape of gastrointestinal stromal tumors and how it can be used to optimize clinical treatment. The overarching goal of this project is to establish a relationship between a patient?s genetic abnormality and the cancer it will initiate in order to guide clinical practice.
DO  - 10.6083/m49k49rk
DO  - DOI
AB  - This dissertation explores the importance of understanding the genetic mechanisms that lead to cancer. Specifically, in Chapter 2 succinate dehydrogenase subunit A variants of unknown significance are categorized based on how they affect succinate dehydrogenase complex function and therefore whether or not they predispose patients to succinate dehydrogenase-deficient cancer. Chapter 3 works to identify novel mechanisms of succinate dehydrogenase-deficiency in tumors with an unknown molecular classification. Finally, Chapter 4 reviews the genetic landscape of gastrointestinal stromal tumors and how it can be used to optimize clinical treatment. The overarching goal of this project is to establish a relationship between a patient?s genetic abnormality and the cancer it will initiate in order to guide clinical practice.
T1  - Translating genetic data into actionable clinical guidelines: succinate dehydrogenase subunit a variants of unknown significance in gastrointestinal stromal tumors
DA  - 2017
AU  - Bannon, Amber E.
L1  - https://digitalcollections.ohsu.edu/record/7613/files/Bannon.Amber.2017.pdf
PB  - Oregon Health and Science University
PY  - 2017
ID  - 7613
L4  - https://digitalcollections.ohsu.edu/record/7613/files/Bannon.Amber.2017.pdf
KW  - Gastrointestinal Stromal Tumors
KW  - Neoplasms
KW  - Saccharomyces cerevisiae
KW  - Hematoma
KW  - chronic
KW  - subdural
TI  - Translating genetic data into actionable clinical guidelines: succinate dehydrogenase subunit a variants of unknown significance in gastrointestinal stromal tumors
Y1  - 2017
L2  - https://digitalcollections.ohsu.edu/record/7613/files/Bannon.Amber.2017.pdf
LK  - https://digitalcollections.ohsu.edu/record/7613/files/Bannon.Amber.2017.pdf
UR  - https://digitalcollections.ohsu.edu/record/7613/files/Bannon.Amber.2017.pdf
ER  -