000007613 001__ 7613
000007613 005__ 20240124114247.0
000007613 0247_ $$2DOI$$a10.6083/m49k49rk
000007613 037__ $$aETD
000007613 245__ $$aTranslating genetic data into actionable clinical guidelines: succinate dehydrogenase subunit a variants of unknown significance in gastrointestinal stromal tumors
000007613 260__ $$bOregon Health and Science University
000007613 269__ $$a2017
000007613 336__ $$aDissertation
000007613 502__ $$bPh.D.
000007613 520__ $$aThis dissertation explores the importance of understanding the genetic mechanisms that lead to cancer. Specifically, in Chapter 2 succinate dehydrogenase subunit A variants of unknown significance are categorized based on how they affect succinate dehydrogenase complex function and therefore whether or not they predispose patients to succinate dehydrogenase-deficient cancer. Chapter 3 works to identify novel mechanisms of succinate dehydrogenase-deficiency in tumors with an unknown molecular classification. Finally, Chapter 4 reviews the genetic landscape of gastrointestinal stromal tumors and how it can be used to optimize clinical treatment. The overarching goal of this project is to establish a relationship between a patient?s genetic abnormality and the cancer it will initiate in order to guide clinical practice.
000007613 542__ $$fIn copyright - single owner
000007613 650__ $$aGastrointestinal Stromal Tumors$$035784
000007613 650__ $$aNeoplasms$$022758
000007613 650__ $$aSaccharomyces cerevisiae$$025647
000007613 650__ $$aHematoma$$020010
000007613 6531_ $$achronic
000007613 6531_ $$asubdural
000007613 691__ $$aSchool of Medicine$$041369
000007613 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000007613 7001_ $$aBannon, Amber E.
000007613 8564_ $$92f8a20fa-cbe6-4474-9330-dd0a6d340728$$s4884828$$uhttps://digitalcollections.ohsu.edu/record/7613/files/Bannon.Amber.2017.pdf
000007613 905__ $$a/rest/prod/hh/63/sw/55/hh63sw55h
000007613 909CO $$ooai:digitalcollections.ohsu.edu:7613$$pstudent-work
000007613 980__ $$aTheses and Dissertations