@article{ETD,
      school = {Ph.D.},
      author = {Guo, Qiuchen},
      url = {http://digitalcollections.ohsu.edu/record/7615},
      title = {Investigating the role of involution mammary fibroblasts  in promoting postpartum breast cancer},
      publisher = {Oregon Health and Science University},
      abstract = {Postpartum breast cancer, which is breast cancer diagnosed  within 5 to 10 years of childbirth, has poor outcomes  compared to breast cancer in age-matched nulliparous or  pregnant women, regardless of the breast cancer subtypes,  tumor stage or year of diagnosis. In preclinical mouse  models, tumor cells show increased proliferation, invasion  and metastatic capacities when injected into the involuting  mammary gland, compared with the nulliparous mammary gland.  Investigations of the microenvironment of the involuting  mammary gland that may contribute to tumor promotion reveal  increased fibrillar collagen abundance. Collagen abundance  and structure regulation is closely associated with breast  cancer risk and progression, and here we hypothesize that  increased collagen deposition and structure remodeling  occurring during weaning-induced involution is similar to  tumor associated collagen, referred to as TACS3, which  independently predicts poor outcomes in breast cancer  patients.},
      number = {ETD},
      doi = {https://doi.org/10.6083/m4bc3xp0},
      recid = {7615},
      address = {2017},
}