TY - GEN AB - Postpartum breast cancer, which is breast cancer diagnosed within 5 to 10 years of childbirth, has poor outcomes compared to breast cancer in age-matched nulliparous or pregnant women, regardless of the breast cancer subtypes, tumor stage or year of diagnosis. In preclinical mouse models, tumor cells show increased proliferation, invasion and metastatic capacities when injected into the involuting mammary gland, compared with the nulliparous mammary gland. Investigations of the microenvironment of the involuting mammary gland that may contribute to tumor promotion reveal increased fibrillar collagen abundance. Collagen abundance and structure regulation is closely associated with breast cancer risk and progression, and here we hypothesize that increased collagen deposition and structure remodeling occurring during weaning-induced involution is similar to tumor associated collagen, referred to as TACS3, which independently predicts poor outcomes in breast cancer patients. AU - Guo, Qiuchen DA - 2017 DO - 10.6083/m4bc3xp0 DO - DOI ID - 7615 KW - Ibuprofen KW - Collagen KW - Weaning KW - Fibroblasts KW - Monocytes KW - human KW - mammary glands L1 - https://digitalcollections.ohsu.edu/record/7615/files/Guo.Qiuchen.2017.pdf L2 - https://digitalcollections.ohsu.edu/record/7615/files/Guo.Qiuchen.2017.pdf L4 - https://digitalcollections.ohsu.edu/record/7615/files/Guo.Qiuchen.2017.pdf LK - https://digitalcollections.ohsu.edu/record/7615/files/Guo.Qiuchen.2017.pdf N2 - Postpartum breast cancer, which is breast cancer diagnosed within 5 to 10 years of childbirth, has poor outcomes compared to breast cancer in age-matched nulliparous or pregnant women, regardless of the breast cancer subtypes, tumor stage or year of diagnosis. In preclinical mouse models, tumor cells show increased proliferation, invasion and metastatic capacities when injected into the involuting mammary gland, compared with the nulliparous mammary gland. Investigations of the microenvironment of the involuting mammary gland that may contribute to tumor promotion reveal increased fibrillar collagen abundance. Collagen abundance and structure regulation is closely associated with breast cancer risk and progression, and here we hypothesize that increased collagen deposition and structure remodeling occurring during weaning-induced involution is similar to tumor associated collagen, referred to as TACS3, which independently predicts poor outcomes in breast cancer patients. PB - Oregon Health and Science University PY - 2017 T1 - Investigating the role of involution mammary fibroblasts in promoting postpartum breast cancer TI - Investigating the role of involution mammary fibroblasts in promoting postpartum breast cancer UR - https://digitalcollections.ohsu.edu/record/7615/files/Guo.Qiuchen.2017.pdf Y1 - 2017 ER -