TY  - GEN
N2  - Postpartum breast cancer, which is breast cancer diagnosed within 5 to 10 years of childbirth, has poor outcomes compared to breast cancer in age-matched nulliparous or pregnant women, regardless of the breast cancer subtypes, tumor stage or year of diagnosis. In preclinical mouse models, tumor cells show increased proliferation, invasion and metastatic capacities when injected into the involuting mammary gland, compared with the nulliparous mammary gland. Investigations of the microenvironment of the involuting mammary gland that may contribute to tumor promotion reveal increased fibrillar collagen abundance. Collagen abundance and structure regulation is closely associated with breast cancer risk and progression, and here we hypothesize that increased collagen deposition and structure remodeling occurring during weaning-induced involution is similar to tumor associated collagen, referred to as TACS3, which independently predicts poor outcomes in breast cancer patients.
DO  - 10.6083/m4bc3xp0
DO  - DOI
AB  - Postpartum breast cancer, which is breast cancer diagnosed within 5 to 10 years of childbirth, has poor outcomes compared to breast cancer in age-matched nulliparous or pregnant women, regardless of the breast cancer subtypes, tumor stage or year of diagnosis. In preclinical mouse models, tumor cells show increased proliferation, invasion and metastatic capacities when injected into the involuting mammary gland, compared with the nulliparous mammary gland. Investigations of the microenvironment of the involuting mammary gland that may contribute to tumor promotion reveal increased fibrillar collagen abundance. Collagen abundance and structure regulation is closely associated with breast cancer risk and progression, and here we hypothesize that increased collagen deposition and structure remodeling occurring during weaning-induced involution is similar to tumor associated collagen, referred to as TACS3, which independently predicts poor outcomes in breast cancer patients.
T1  - Investigating the role of involution mammary fibroblasts in promoting postpartum breast cancer
DA  - 2017
AU  - Guo, Qiuchen
L1  - https://digitalcollections.ohsu.edu/record/7615/files/Guo.Qiuchen.2017.pdf
PB  - Oregon Health and Science University
PY  - 2017
ID  - 7615
L4  - https://digitalcollections.ohsu.edu/record/7615/files/Guo.Qiuchen.2017.pdf
KW  - Ibuprofen
KW  - Collagen
KW  - Weaning
KW  - Fibroblasts
KW  - Monocytes
KW  - human
KW  - mammary glands
TI  - Investigating the role of involution mammary fibroblasts in promoting postpartum breast cancer
Y1  - 2017
L2  - https://digitalcollections.ohsu.edu/record/7615/files/Guo.Qiuchen.2017.pdf
LK  - https://digitalcollections.ohsu.edu/record/7615/files/Guo.Qiuchen.2017.pdf
UR  - https://digitalcollections.ohsu.edu/record/7615/files/Guo.Qiuchen.2017.pdf
ER  -