000007615 001__ 7615
000007615 005__ 20240124114247.0
000007615 0247_ $$2DOI$$a10.6083/m4bc3xp0
000007615 037__ $$aETD
000007615 245__ $$aInvestigating the role of involution mammary fibroblasts in promoting postpartum breast cancer
000007615 260__ $$bOregon Health and Science University
000007615 269__ $$a2017
000007615 336__ $$aDissertation
000007615 502__ $$bPh.D.
000007615 520__ $$aPostpartum breast cancer, which is breast cancer diagnosed within 5 to 10 years of childbirth, has poor outcomes compared to breast cancer in age-matched nulliparous or pregnant women, regardless of the breast cancer subtypes, tumor stage or year of diagnosis. In preclinical mouse models, tumor cells show increased proliferation, invasion and metastatic capacities when injected into the involuting mammary gland, compared with the nulliparous mammary gland. Investigations of the microenvironment of the involuting mammary gland that may contribute to tumor promotion reveal increased fibrillar collagen abundance. Collagen abundance and structure regulation is closely associated with breast cancer risk and progression, and here we hypothesize that increased collagen deposition and structure remodeling occurring during weaning-induced involution is similar to tumor associated collagen, referred to as TACS3, which independently predicts poor outcomes in breast cancer patients.
000007615 542__ $$fIn copyright - single owner
000007615 650__ $$aIbuprofen$$020616
000007615 650__ $$aCollagen$$016890
000007615 650__ $$aWeaning$$027950
000007615 650__ $$aFibroblasts$$019020
000007615 650__ $$aMonocytes$$022414
000007615 6531_ $$ahuman
000007615 6531_ $$amammary glands
000007615 691__ $$aSchool of Medicine$$041369
000007615 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000007615 7001_ $$aGuo, Qiuchen
000007615 8564_ $$96dacea1c-ca24-4f8e-a778-f1ef9f4e7a9e$$s14113481$$uhttps://digitalcollections.ohsu.edu/record/7615/files/Guo.Qiuchen.2017.pdf
000007615 905__ $$a/rest/prod/3x/81/6n/29/3x816n29v
000007615 909CO $$ooai:digitalcollections.ohsu.edu:7615$$pstudent-work
000007615 980__ $$aTheses and Dissertations