TY - GEN AB - Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes acute febrile illness and long-lasting joint and muscle pain. The 2013-2016 CHIKV outbreaks in the Americas is one example of how CHIKV can rapidly spread through areas of CHIKV seronegative individuals and cause widespread severe and debilitating arthritic disease. Since there is no currently available licensed vaccine or antiviral for preventing or treating CHIKV and other alphaviruses, there is urgent need to understand the basic processes of viral replication and viral immunity to develop effective prophylactic and therapeutic treatments. In my dissertation, I describe three different strategies to uncover new aspects of CHIKV biology by testing a small molecule inhibitor, a monoclonal antibody therapy, and a novel T cell vaccine. AU - Broeckel, Rebecca DA - 2017 DO - 10.6083/m4bc3z3s DO - DOI ID - 7616 KW - Alphavirus KW - Chikungunya virus KW - vaccines antibodies KW - viral L1 - https://digitalcollections.ohsu.edu/record/7616/files/Broeckel.Rebecca.2017.pdf L2 - https://digitalcollections.ohsu.edu/record/7616/files/Broeckel.Rebecca.2017.pdf L4 - https://digitalcollections.ohsu.edu/record/7616/files/Broeckel.Rebecca.2017.pdf LK - https://digitalcollections.ohsu.edu/record/7616/files/Broeckel.Rebecca.2017.pdf N2 - Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes acute febrile illness and long-lasting joint and muscle pain. The 2013-2016 CHIKV outbreaks in the Americas is one example of how CHIKV can rapidly spread through areas of CHIKV seronegative individuals and cause widespread severe and debilitating arthritic disease. Since there is no currently available licensed vaccine or antiviral for preventing or treating CHIKV and other alphaviruses, there is urgent need to understand the basic processes of viral replication and viral immunity to develop effective prophylactic and therapeutic treatments. In my dissertation, I describe three different strategies to uncover new aspects of CHIKV biology by testing a small molecule inhibitor, a monoclonal antibody therapy, and a novel T cell vaccine. PB - Oregon Health and Science University PY - 2017 T1 - Discovering new vaccines and therapeutics to treat chikungunya virus infections: characterization of an antiviral, a therapy, and a vaccine TI - Discovering new vaccines and therapeutics to treat chikungunya virus infections: characterization of an antiviral, a therapy, and a vaccine UR - https://digitalcollections.ohsu.edu/record/7616/files/Broeckel.Rebecca.2017.pdf Y1 - 2017 ER -