TY  - GEN
N2  - Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes acute febrile illness and long-lasting joint and muscle pain. The 2013-2016 CHIKV outbreaks in the Americas is one example of how CHIKV can rapidly spread through areas of CHIKV seronegative individuals and cause widespread severe and debilitating arthritic disease. Since there is no currently available licensed vaccine or antiviral for preventing or treating CHIKV and other alphaviruses, there is urgent need to understand the basic processes of viral replication and viral immunity to develop effective prophylactic and therapeutic treatments. In my dissertation, I describe three different strategies to uncover new aspects of CHIKV biology by testing a small molecule inhibitor, a monoclonal antibody therapy, and a novel T cell vaccine.
DO  - 10.6083/m4bc3z3s
DO  - DOI
AB  - Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes acute febrile illness and long-lasting joint and muscle pain. The 2013-2016 CHIKV outbreaks in the Americas is one example of how CHIKV can rapidly spread through areas of CHIKV seronegative individuals and cause widespread severe and debilitating arthritic disease. Since there is no currently available licensed vaccine or antiviral for preventing or treating CHIKV and other alphaviruses, there is urgent need to understand the basic processes of viral replication and viral immunity to develop effective prophylactic and therapeutic treatments. In my dissertation, I describe three different strategies to uncover new aspects of CHIKV biology by testing a small molecule inhibitor, a monoclonal antibody therapy, and a novel T cell vaccine.
T1  - Discovering new vaccines and therapeutics to treat chikungunya virus infections: characterization of an antiviral, a therapy, and a vaccine
DA  - 2017
AU  - Broeckel, Rebecca
L1  - https://digitalcollections.ohsu.edu/record/7616/files/Broeckel.Rebecca.2017.pdf
PB  - Oregon Health and Science University
PY  - 2017
ID  - 7616
L4  - https://digitalcollections.ohsu.edu/record/7616/files/Broeckel.Rebecca.2017.pdf
KW  - Alphavirus
KW  - Chikungunya virus
KW  - vaccines antibodies
KW  - viral
TI  - Discovering new vaccines and therapeutics to treat chikungunya virus infections: characterization of an antiviral, a therapy, and a vaccine
Y1  - 2017
L2  - https://digitalcollections.ohsu.edu/record/7616/files/Broeckel.Rebecca.2017.pdf
LK  - https://digitalcollections.ohsu.edu/record/7616/files/Broeckel.Rebecca.2017.pdf
UR  - https://digitalcollections.ohsu.edu/record/7616/files/Broeckel.Rebecca.2017.pdf
ER  -