000007624 001__ 7624
000007624 005__ 20231129124935.0
000007624 0247_ $$2DOI$$a10.6083/m4cv4h9m
000007624 037__ $$aETD
000007624 245__ $$aThe development of chemical tools  for investigating the functional roles of the poly(adp-ribose) polymerase (parp) family
000007624 260__ $$bOregon Health and Science University
000007624 269__ $$a2017
000007624 336__ $$aDissertation
000007624 502__ $$bPh.D.
000007624 520__ $$aThe poly (ADP-ribose) polymerase (PARP) family catalyzes the post-translational modification known as ADP-ribosylation (ADPr) from donor molecule nicotinamide adenine dinucleotide (NAD+). The PARP family consists of 17 members (in humans) based upon a conserved catalytic domain. The family is further divided based on whether they catalyze mono-ADPr, the transfer of a single ADP-ribose to protein targets, or poly-ADPr, the transfer of additional ADP-ribose units onto the initial ADP-ribose modification. The poly-ADPr PARPs have been extensively studied, most notably PARP1 and PARP2, for their involvement in DNA damage recognition and repair. The mono-ADPr PARPs have only recently been investigated in various roles throughout the cell. Their study has been limited mostly to knockdown techniques to identify cellular phenotypes. These genetic approaches remove the PARP from the cellular system and do not provide the ability to identify specific targets of PARPs, nor do they allow a dynamic study of PARP biology. They also preclude the ability to connect PARP catalytic activity to a given process without ruling out other domain features within PARPs.
000007624 542__ $$fIn copyright - single owner
000007624 650__ $$aClick Chemistry$$039046
000007624 650__ $$aMolecular Probes$$028331
000007624 650__ $$aPoly(ADP-ribose) Polymerase Inhibitors$$011198
000007624 650__ $$aProtein Engineering$$028214
000007624 650__ $$aNAD$$022641
000007624 650__ $$aADP Ribose Transferases$$034709
000007624 691__ $$aSchool of Medicine$$041369
000007624 692__ $$aDepartment of Physiology and Pharmacology$$041442
000007624 7001_ $$aMorgan, Rory K.
000007624 8564_ $$96e116b99-777c-4fc8-8bd7-a8d73665c58e$$s6722290$$uhttps://digitalcollections.ohsu.edu/record/7624/files/Morgan.Rory.2017.pdf
000007624 905__ $$a/rest/prod/xw/42/n8/46/xw42n846z
000007624 909CO $$ooai:digitalcollections.ohsu.edu:7624$$pstudent-work
000007624 980__ $$aTheses and Dissertations