@article{ETD,
      school = {Ph.D.},
      author = {Lam, Wai Y.},
      url = {http://digitalcollections.ohsu.edu/record/7638},
      title = {Spatiotemporal dynamics of human epidermal growth factor  receptor 2 (her2) protrusion signaling},
      publisher = {Oregon Health and Science University},
      abstract = {Signal transduction entails the precise interaction of  relevant proteins for transmission of signaling pathways  that carry out essential functions. In cancer, dysregulated  protrusion growth underlies metastasis and disease  progression.  Breast cancer cell protrusions express HER2  and HER2 has been linked to protrusion growth, but details  of how HER2 signaling is conducted in protrusions remains  unclear.  Here, I demonstrate a sensitive and quantitative  method for analyzing the expression and spatial  localization of HER2 and pAKT using quantum dots (QDs).  I  also employ novel monovalent HER2-QD probes using various  imaging modalities (single particle tracking, EM, and  super-resolution) to characterize the spatiotemporal  features of HER2 signaling in breast cancer cell  protrusions.},
      number = {ETD},
      doi = {https://doi.org/10.6083/m4gm86v3},
      recid = {7638},
      address = {2017},
}