TY  - GEN
N2  - Signal transduction entails the precise interaction of relevant proteins for transmission of signaling pathways that carry out essential functions. In cancer, dysregulated protrusion growth underlies metastasis and disease progression.  Breast cancer cell protrusions express HER2 and HER2 has been linked to protrusion growth, but details of how HER2 signaling is conducted in protrusions remains unclear.  Here, I demonstrate a sensitive and quantitative method for analyzing the expression and spatial localization of HER2 and pAKT using quantum dots (QDs).  I also employ novel monovalent HER2-QD probes using various imaging modalities (single particle tracking, EM, and super-resolution) to characterize the spatiotemporal features of HER2 signaling in breast cancer cell protrusions.
DO  - 10.6083/m4gm86v3
DO  - DOI
AB  - Signal transduction entails the precise interaction of relevant proteins for transmission of signaling pathways that carry out essential functions. In cancer, dysregulated protrusion growth underlies metastasis and disease progression.  Breast cancer cell protrusions express HER2 and HER2 has been linked to protrusion growth, but details of how HER2 signaling is conducted in protrusions remains unclear.  Here, I demonstrate a sensitive and quantitative method for analyzing the expression and spatial localization of HER2 and pAKT using quantum dots (QDs).  I also employ novel monovalent HER2-QD probes using various imaging modalities (single particle tracking, EM, and super-resolution) to characterize the spatiotemporal features of HER2 signaling in breast cancer cell protrusions.
T1  - Spatiotemporal dynamics of human epidermal growth factor receptor 2 (her2) protrusion signaling
DA  - 2017
AU  - Lam, Wai Y.
L1  - https://digitalcollections.ohsu.edu/record/7638/files/Lam.Wai.2017.pdf
PB  - Oregon Health and Science University
PY  - 2017
ID  - 7638
L4  - https://digitalcollections.ohsu.edu/record/7638/files/Lam.Wai.2017.pdf
KW  - ErbB Receptors
KW  - Actins
KW  - Pseudopodia
TI  - Spatiotemporal dynamics of human epidermal growth factor receptor 2 (her2) protrusion signaling
Y1  - 2017
L2  - https://digitalcollections.ohsu.edu/record/7638/files/Lam.Wai.2017.pdf
LK  - https://digitalcollections.ohsu.edu/record/7638/files/Lam.Wai.2017.pdf
UR  - https://digitalcollections.ohsu.edu/record/7638/files/Lam.Wai.2017.pdf
ER  -