000007646 001__ 7646
000007646 005__ 20231129124935.0
000007646 0247_ $$2DOI$$a10.6083/m4m61jdv
000007646 037__ $$aETD
000007646 245__ $$aSynaptic computations in the olfactory bulb glomerular microcircuit
000007646 260__ $$bOregon Health and Science University
000007646 269__ $$a2017
000007646 336__ $$aDissertation
000007646 502__ $$bPh.D.
000007646 520__ $$aI used whole-cell voltage clamp and current clamp recordings in acute mouse olfactory bulb slices.  I first demonstrate that a population of juxtaglomerular interneurons, which release both dopamine and GABA, can effectively inhibit transmitter release from primary afferent neurons, thereby potently controlling the strength of afferent input.  Using single glomerular afferent stimulation, I further demonstrate that the afferent olfactory receptor nerve terminal has an extraordinarily high release probability, which is mediated by a single pool of slowly recycling vesicles. This work provides important insight into the divergent synaptic processing of common olfactory input, and defines the synaptic mechanisms underlying parallel processing of afferent input.
000007646 542__ $$fIn copyright - single owner
000007646 691__ $$aSchool of Medicine$$041369
000007646 692__ $$aVollum Institute$$041509
000007646 7001_ $$aVaaga, Christopher E.
000007646 8564_ $$9e8539b8a-1c8d-423c-8f6a-fcc86f72b6a2$$s45496904$$uhttps://digitalcollections.ohsu.edu/record/7646/files/Vaaga.Christopher.2017.pdf
000007646 905__ $$a/rest/prod/0v/83/81/14/0v838114w
000007646 909CO $$ooai:digitalcollections.ohsu.edu:7646$$pstudent-work
000007646 980__ $$aTheses and Dissertations