000007649 001__ 7649
000007649 005__ 20231214104146.0
000007649 0247_ $$2DOI$$a10.6083/m4n58kw5
000007649 037__ $$aETD
000007649 245__ $$aBatch effect detection and network analysis in BCR/ABL-independent CML imatinib resistance
000007649 260__ $$bOregon Health and Science University
000007649 260__ $$bOregon Health and Science University
000007649 269__ $$a2017
000007649 336__ $$aThesis
000007649 502__ $$bM.S.
000007649 520__ $$aDue to the complexity of BCR/ABL-independent TKI resistance, a central question is whether relapse acts through the canonical BCR/ABL CML pathways seen in dependent cases, or through a different set of genes and pathways. To answer this question, both RNA-seq and Whole Exome Sequencing data was collected and analyzed as part of a large retrospective study of CML patients with acquired resistance to imatinib and other related TKI inhibitors. RNA-seq and Whole Exome sequencing are both next generation sequencing approaches which allow for the high-throughput, cost-effective characterization of an individual's entire mRNA transcript profile (RNAseq) or protein coding region of the genome (WES)[15]. This study was comprised of 244 samples (123 WES, 121 RNAseq) collected from seven different clinical locations across the United States and Europe. These samples represented 130 unique patients, 70 of which had samples collected for both data types, 36 for WES only, and 24 for RNAseq only.
000007649 542__ $$fIn copyright - single owner
000007649 650__ $$aPrecision Medicine$$038927
000007649 650__ $$aDrug Resistance$$018079
000007649 650__ $$aLeukemia$$021430
000007649 650__ $$aComputational Biology$$031511
000007649 650__ $$aMolecular Targeted Therapy$$039450
000007649 650__ $$aAlgorithms$$014437
000007649 691__ $$aSchool of Medicine$$041369
000007649 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000007649 7001_ $$aTherneau, Adam$$uOregon Health and Science University$$041354
000007649 8564_ $$948ea0f4d-b32e-48f8-9f22-ddd3c231ef24$$s6336341$$uhttps://digitalcollections.ohsu.edu/record/7649/files/Therneau.Adam.2017.pdf
000007649 905__ $$a/rest/prod/3n/20/3z/63/3n203z636
000007649 909CO $$ooai:digitalcollections.ohsu.edu:7649$$pstudent-work
000007649 980__ $$aBiomedical Informatics