TY  - GEN
AB  - Asthma is a chronic inflammatory disease characterized by airway hyperreactivity, partly driven by sensory neuron dysfunction. This dissertation introduces a novel whole-organ nerve visualization and quantification method to study neuroplasticity in asthma. Using this approach, we show that eosinophils promote branched outgrowth of airway nerves in chronic, but not acute, allergic inflammation, leading to increased reflex bronchoconstriction. Transgenic eosinophil-deficient mice confirmed eosinophil necessity for these changes. Similar eosinophil-driven neuroplasticity was observed in atopic dermatitis models and co-culture experiments. These findings reveal eosinophil-mediated neuroimmune interactions as key contributors to asthma morbidity and allergic disease pathogenesis.
AD  - Oregon Health and Science University
AU  - Scott, Gregory
DA  - 2012
DO  - 10.6083/M4RN35VM
DO  - DOI
ED  - Jacoby, David
ED  - Advisor
ED  - Mentor
ID  - 765
KW  - Peripheral Nervous System
KW  - Asthma
KW  - Neuroimmunomodulation
KW  - Neuronal Plasticity
KW  - Eosinophils
KW  - Peripheral Nerves
KW  - neuroimmunology
L1  - https://digitalcollections.ohsu.edu/record/765/files/768_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/765/files/768_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/765/files/768_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/765/files/768_etd.pdf
N2  - Asthma is a chronic inflammatory disease characterized by airway hyperreactivity, partly driven by sensory neuron dysfunction. This dissertation introduces a novel whole-organ nerve visualization and quantification method to study neuroplasticity in asthma. Using this approach, we show that eosinophils promote branched outgrowth of airway nerves in chronic, but not acute, allergic inflammation, leading to increased reflex bronchoconstriction. Transgenic eosinophil-deficient mice confirmed eosinophil necessity for these changes. Similar eosinophil-driven neuroplasticity was observed in atopic dermatitis models and co-culture experiments. These findings reveal eosinophil-mediated neuroimmune interactions as key contributors to asthma morbidity and allergic disease pathogenesis.
PB  - Oregon Health and Science University
PY  - 2012
T1  - Sensory neuroplasticity in asthma
TI  - Sensory neuroplasticity in asthma
UR  - https://digitalcollections.ohsu.edu/record/765/files/768_etd.pdf
Y1  - 2012
ER  -