000000765 001__ 765
000000765 005__ 20260120144838.0
000000765 0247_ $$2DOI$$a10.6083/M4RN35VM
000000765 037__ $$aETD
000000765 245__ $$aSensory neuroplasticity in asthma
000000765 260__ $$bOregon Health and Science University
000000765 269__ $$a2012
000000765 336__ $$aDissertation
000000765 502__ $$bPh.D.
000000765 520__ $$aAsthma is a chronic inflammatory disease characterized by airway hyperreactivity, partly driven by sensory neuron dysfunction. This dissertation introduces a novel whole-organ nerve visualization and quantification method to study neuroplasticity in asthma. Using this approach, we show that eosinophils promote branched outgrowth of airway nerves in chronic, but not acute, allergic inflammation, leading to increased reflex bronchoconstriction. Transgenic eosinophil-deficient mice confirmed eosinophil necessity for these changes. Similar eosinophil-driven neuroplasticity was observed in atopic dermatitis models and co-culture experiments. These findings reveal eosinophil-mediated neuroimmune interactions as key contributors to asthma morbidity and allergic disease pathogenesis.
000000765 540__ $$fCC BY
000000765 542__ $$fIn copyright - single owner
000000765 650__ $$aPeripheral Nervous System$$030360
000000765 650__ $$aAsthma$$015168
000000765 650__ $$aNeuroimmunomodulation$$028223
000000765 650__ $$aNeuronal Plasticity$$022857
000000765 650__ $$aEosinophils$$018511
000000765 650__ $$aPeripheral Nerves$$023837
000000765 6531_ $$aneuroimmunology
000000765 691__ $$aSchool of Medicine$$041369
000000765 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000000765 7001_ $$aScott, Gregory$$uOregon Health and Science University$$041354
000000765 7201_ $$aJacoby, David$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000765 8564_ $$9712dbd3d-e936-4f86-ab1d-e982d6d8e62a$$s61620172$$uhttps://digitalcollections.ohsu.edu/record/765/files/768_etd.pdf$$ePublic$$221b1d8891758ad2829f56073275baf05$$31
000000765 905__ $$a/rest/prod/q2/37/hr/97/q237hr97c
000000765 909CO $$ooai:digitalcollections.ohsu.edu:765$$pstudent-work
000000765 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000765 980__ $$aTheses and Dissertations