@article{ETD, recid = {7650}, author = {Nelson, Nathan}, title = {Developmental effects of nonuniform acetylcholine receptor expression on motor neuron and synapse morphology in larval zebrafish}, publisher = {Oregon Health and Science University}, school = {M.S.}, address = {2017}, number = {ETD}, abstract = {It is well established that altered postsynaptic receptor activity leads to changes in presynaptic transmission and presynaptic connectivity throughout the nervous system. Receptor-activity-dependent modulation of presynaptic transmission, termed "synaptic plasticity", was first highlighted from studies at neuromuscular synapses and later recapitulated at central synapses. The receptor-activity-dependent process responsible for reducing the number of presynaptic inputs from multiple neurons onto a target cell throughout synapse development, a form of synaptic competition, was also first demonstrated at the neuromuscular junction (NMJ) and later observed at central synapses. This study, however, probes for evidence of receptor-activity-dependent intra-neuronal competition between axon terminals from the same motor neuron.}, url = {http://digitalcollections.ohsu.edu/record/7650}, doi = {https://doi.org/10.6083/m4nc60q6}, }