TY - THES AB - Diabetes mellitus is a group of metabolic disorders characterized by prolonged elevation of blood glucose levels, inducing numerous complications such as retinopathy, kidney disease, heart disease and stroke. β cells in the pancreatic islets are responsible for regulating blood glucose levels through secretion of insulin, which stimulates cells in the body to take up glucose from the blood. This process is disrupted in diabetes patients, who either suffer from autoimmune induced β cell death (type 1 diabetes, insulin deficiency) or fail to respond to insulin signaling (type 2 diabetes, insulin resistance). In this dissertation, I will discuss interesting findings stemming from this study, which suggests that the donor cell type of origin influences the molecular and functional properties of reprogrammed cells. Reprogramming approaches developed in this dissertation offer alternative treatment strategies for type 1 diabetes patients and the experimental observations made through using different cell types and reprogramming factors for cell fate conversion shed light on the mechanisms of the direct lineage reprogramming process. AU - Wang, Yuhan DA - 2017 DO - 10.6083/m4zs2w1d DO - DOI ID - 7659 KW - Cell Transdifferentiation KW - Pancreas KW - Cell Lineage KW - Genetic Therapy KW - Cell- and Tissue-Based Therapy KW - Insulin KW - type 1 diabetes mellitus L1 - https://digitalcollections.ohsu.edu/record/7659/files/Wang.Yuhan.2017.pdf L2 - https://digitalcollections.ohsu.edu/record/7659/files/Wang.Yuhan.2017.pdf L4 - https://digitalcollections.ohsu.edu/record/7659/files/Wang.Yuhan.2017.pdf LK - https://digitalcollections.ohsu.edu/record/7659/files/Wang.Yuhan.2017.pdf N2 - Diabetes mellitus is a group of metabolic disorders characterized by prolonged elevation of blood glucose levels, inducing numerous complications such as retinopathy, kidney disease, heart disease and stroke. β cells in the pancreatic islets are responsible for regulating blood glucose levels through secretion of insulin, which stimulates cells in the body to take up glucose from the blood. This process is disrupted in diabetes patients, who either suffer from autoimmune induced β cell death (type 1 diabetes, insulin deficiency) or fail to respond to insulin signaling (type 2 diabetes, insulin resistance). In this dissertation, I will discuss interesting findings stemming from this study, which suggests that the donor cell type of origin influences the molecular and functional properties of reprogrammed cells. Reprogramming approaches developed in this dissertation offer alternative treatment strategies for type 1 diabetes patients and the experimental observations made through using different cell types and reprogramming factors for cell fate conversion shed light on the mechanisms of the direct lineage reprogramming process. PB - Oregon Health and Science University PY - 2017 T1 - Cellular plasticity within the endoderm: lessons learned from direct lineage reprogramming into pancreatic [beta] cells TI - Cellular plasticity within the endoderm: lessons learned from direct lineage reprogramming into pancreatic [beta] cells UR - https://digitalcollections.ohsu.edu/record/7659/files/Wang.Yuhan.2017.pdf Y1 - 2017 ER -