TY  - THES
N2  - Diabetes  mellitus  is  a  group  of  metabolic  disorders  characterized  by  prolonged  elevation  of 
blood  glucose  levels,  inducing  numerous  complications  such  as  retinopathy,  kidney  disease, 
heart  disease  and  stroke.  β  cells  in  the  pancreatic  islets  are  responsible  for  regulating  blood 
glucose levels through secretion of insulin, which stimulates cells in the body to take up glucose 
from the blood. This process is disrupted in diabetes patients, who either suffer from 
autoimmune induced β cell death (type 1 diabetes, insulin deficiency) or fail to respond to insulin 
signaling (type 2 diabetes, insulin resistance). In this dissertation, I will discuss interesting findings stemming from this study, which suggests that the donor cell type of origin influences the molecular and functional properties of reprogrammed cells. Reprogramming approaches developed in this dissertation offer alternative treatment strategies for type 1 diabetes patients and the experimental observations made through using different cell types and reprogramming factors for cell fate conversion shed light on the mechanisms of the direct lineage reprogramming process.
DO  - 10.6083/m4zs2w1d
DO  - DOI
AB  - Diabetes  mellitus  is  a  group  of  metabolic  disorders  characterized  by  prolonged  elevation  of 
blood  glucose  levels,  inducing  numerous  complications  such  as  retinopathy,  kidney  disease, 
heart  disease  and  stroke.  β  cells  in  the  pancreatic  islets  are  responsible  for  regulating  blood 
glucose levels through secretion of insulin, which stimulates cells in the body to take up glucose 
from the blood. This process is disrupted in diabetes patients, who either suffer from 
autoimmune induced β cell death (type 1 diabetes, insulin deficiency) or fail to respond to insulin 
signaling (type 2 diabetes, insulin resistance). In this dissertation, I will discuss interesting findings stemming from this study, which suggests that the donor cell type of origin influences the molecular and functional properties of reprogrammed cells. Reprogramming approaches developed in this dissertation offer alternative treatment strategies for type 1 diabetes patients and the experimental observations made through using different cell types and reprogramming factors for cell fate conversion shed light on the mechanisms of the direct lineage reprogramming process.
T1  - Cellular plasticity within the endoderm: lessons learned from direct lineage reprogramming into pancreatic [beta] cells
DA  - 2017
AU  - Wang, Yuhan
L1  - https://digitalcollections.ohsu.edu/record/7659/files/Wang.Yuhan.2017.pdf
PB  - Oregon Health and Science University
PY  - 2017
ID  - 7659
L4  - https://digitalcollections.ohsu.edu/record/7659/files/Wang.Yuhan.2017.pdf
KW  - Cell Transdifferentiation 
KW  - Pancreas 
KW  - Cell Lineage
KW  - Genetic Therapy 
KW  - Cell- and Tissue-Based Therapy 
KW  - Insulin 
KW  - type 1 diabetes mellitus
TI  - Cellular plasticity within the endoderm: lessons learned from direct lineage reprogramming into pancreatic [beta] cells
Y1  - 2017
L2  - https://digitalcollections.ohsu.edu/record/7659/files/Wang.Yuhan.2017.pdf
LK  - https://digitalcollections.ohsu.edu/record/7659/files/Wang.Yuhan.2017.pdf
UR  - https://digitalcollections.ohsu.edu/record/7659/files/Wang.Yuhan.2017.pdf
ER  -