000007659 001__ 7659
000007659 005__ 20240124114248.0
000007659 0247_ $$2DOI$$a10.6083/m4zs2w1d
000007659 037__ $$aETD
000007659 245__ $$aCellular plasticity within the endoderm: lessons learned from direct lineage reprogramming into pancreatic [beta] cells
000007659 260__ $$bOregon Health and Science University
000007659 269__ $$a2017
000007659 336__ $$aThesis
000007659 502__ $$bPh.D.
000007659 520__ $$aDiabetes  mellitus  is  a  group  of  metabolic  disorders  characterized  by  prolonged  elevation  of 
blood  glucose  levels,  inducing  numerous  complications  such  as  retinopathy,  kidney  disease, 
heart  disease  and  stroke.  β  cells  in  the  pancreatic  islets  are  responsible  for  regulating  blood 
glucose levels through secretion of insulin, which stimulates cells in the body to take up glucose 
from the blood. This process is disrupted in diabetes patients, who either suffer from 
autoimmune induced β cell death (type 1 diabetes, insulin deficiency) or fail to respond to insulin 
signaling (type 2 diabetes, insulin resistance). In this dissertation, I will discuss interesting findings stemming from this study, which suggests that the donor cell type of origin influences the molecular and functional properties of reprogrammed cells. Reprogramming approaches developed in this dissertation offer alternative treatment strategies for type 1 diabetes patients and the experimental observations made through using different cell types and reprogramming factors for cell fate conversion shed light on the mechanisms of the direct lineage reprogramming process.
000007659 650__ $$aCell Transdifferentiation $$037775
000007659 650__ $$aPancreas $$023506
000007659 650__ $$aCell Lineage$$031332
000007659 650__ $$aGenetic Therapy $$028314
000007659 650__ $$aCell- and Tissue-Based Therapy $$040537
000007659 650__ $$aInsulin $$020872
000007659 6531_ $$atype 1 diabetes mellitus
000007659 691__ $$aSchool of Medicine$$041369
000007659 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000007659 7001_ $$aWang, Yuhan
000007659 8564_ $$9d803a497-4157-4ee8-8034-97878f7fda64$$s12136826$$uhttps://digitalcollections.ohsu.edu/record/7659/files/Wang.Yuhan.2017.pdf
000007659 905__ $$a/rest/prod/fb/49/48/90/fb4948909
000007659 909CO $$ooai:digitalcollections.ohsu.edu:7659$$pstudent-work
000007659 980__ $$aTheses and Dissertations