000007661 001__ 7661
000007661 005__ 20231129124933.0
000007661 0247_ $$2DOI$$a10.6083/m48915d7
000007661 037__ $$aETD
000007661 245__ $$aFunctional analyses of patient-derived tumor cells reveal potential targeted therapies for HNSCC
000007661 260__ $$bOregon Health and Science University
000007661 269__ $$a2017
000007661 336__ $$aDissertation
000007661 502__ $$bPh.D.
000007661 520__ $$aHead and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide, with high morbidity, high mortality, and few therapeutic options outside of surgery, standard cytotoxic chemotherapy, and radiation. Epidermal growth factor receptor (EGFR) is overexpressed in up to 90% of HNSCC and is associated with poor outcome. An EGFR monoclonal antibody, cetuximab, is the only FDA-approved cancer intrinsic molecular targeted therapy for HNSCC; however, resistance eventually occurs in all patients. In my graduate studies, functional screens, including a small-molecule kinase inhibitor screen and siRNA screening panels, were used to identify agents that synergized with EGFR inhibitors in reducing viability in HNSCC patient-derived tumor cells. Bioinformatics analysis was performed to determine the coverage by the drugs on the inhibitor assay of genomic alterations in the HNSCC The Cancer Genome Atlas (TCGA) cohort.
000007661 542__ $$fIn copyright - single owner
000007661 650__ $$aReceptor Protein-Tyrosine Kinases$$032703
000007661 650__ $$aHumans$$020376
000007661 650__ $$aSquamous Cell Carcinoma of Head and Neck$$012663
000007661 650__ $$aHead and Neck Neoplasms$$019866
000007661 650__ $$aMolecular Targeted Therapy$$039450
000007661 691__ $$aSchool of Medicine$$041369
000007661 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000007661 7001_ $$aOuyang, Xiaoming
000007661 8564_ $$955af4d57-2a6e-4f6f-83c2-3e1119daa697$$s5024769$$uhttps://digitalcollections.ohsu.edu/record/7661/files/Ouyang.Xiaoming.2017.pdf
000007661 905__ $$a/rest/prod/m6/13/mz/19/m613mz195
000007661 909CO $$ooai:digitalcollections.ohsu.edu:7661$$pstudent-work
000007661 980__ $$aTheses and Dissertations