@article{ETD,
      recid = {7665},
      author = {Klick, Mark T.},
      title = {Elucidating gut microbiota-immune interactions in an  animal model of ankylosing spondylitis},
      publisher = {Oregon Health and Science University},
      school = {M.S.},
      address = {2017},
      number = {ETD},
      abstract = {Ankylosing​ ​spondylitis​ ​(AS)​ ​is​ ​a​ ​chronic​  ​inflammatory​ ​disorder​ ​in​ ​which​ ​aberrant immune​  ​responses​ ​to​ ​the​ ​intestinal​ ​microbiota​ ​are​  ​thought​ ​to​ ​drive​pathogenesis.​ ​The​ ​HLA-B27  transgenic​ ​rat​ ​is​ ​a​ ​foremost​ ​translational​  ​model​ ​of​ ​disease,​ ​with​ ​rats​ ​expressing​ ​the​  ​major human​ ​risk​ ​allele​ ​for​ ​AS.​ ​We​ ​have​  ​shown​ ​previously​ ​the​ ​IgA​ ​response​ ​to​ ​gut​  ​microbes​ ​is strongly​ ​elevated​ ​in​ ​this​ ​model,​  ​but​ ​the​ ​specificity​ ​of​ ​this​ ​response​ ​remains​  ​unclear.​ ​Here​ ​we used​ ​the​ ​novel​ ​IgA-SEQ​  ​technique​ ​to​ ​test​ ​the​ hypothesis​ ​that​ ​HLA-B27​  ​expression​ ​alters​ ​the microbial​ ​repertoire​ ​of​  ​the​ ​intestinal​ ​IgA​ ​response.},
      url = {http://digitalcollections.ohsu.edu/record/7665},
      doi = {https://doi.org/10.6083/m4rx9bmk},
}