000007665 001__ 7665
000007665 005__ 20240124114249.0
000007665 0247_ $$2DOI$$a10.6083/m4rx9bmk
000007665 037__ $$aETD
000007665 245__ $$aElucidating gut microbiota-immune interactions in an animal model of ankylosing spondylitis
000007665 260__ $$bOregon Health and Science University
000007665 269__ $$a2017
000007665 336__ $$aThesis
000007665 502__ $$bM.S.
000007665 520__ $$aAnkylosing​ ​spondylitis​ ​(AS)​ ​is​ ​a​ ​chronic​ ​inflammatory​ ​disorder​ ​in​ ​which​ ​aberrant immune​ ​responses​ ​to​ ​the​ ​intestinal​ ​microbiota​ ​are​ ​thought​ ​to​ ​drive​pathogenesis.​ ​The​ ​HLA-B27 transgenic​ ​rat​ ​is​ ​a​ ​foremost​ ​translational​ ​model​ ​of​ ​disease,​ ​with​ ​rats​ ​expressing​ ​the​ ​major human​ ​risk​ ​allele​ ​for​ ​AS.​ ​We​ ​have​ ​shown​ ​previously​ ​the​ ​IgA​ ​response​ ​to​ ​gut​ ​microbes​ ​is strongly​ ​elevated​ ​in​ ​this​ ​model,​ ​but​ ​the​ ​specificity​ ​of​ ​this​ ​response​ ​remains​ ​unclear.​ ​Here​ ​we used​ ​the​ ​novel​ ​IgA-SEQ​ ​technique​ ​to​ ​test​ ​the​ hypothesis​ ​that​ ​HLA-B27​ ​expression​ ​alters​ ​the microbial​ ​repertoire​ ​of​ ​the​ ​intestinal​ ​IgA​ ​response.
000007665 650__ $$aImmunoglobulin A $$020630
000007665 650__ $$aComputational Biology $$031511
000007665 650__ $$aMicrobiota$$040384
000007665 6531_ $$aankylosing spondylitis
000007665 691__ $$aSchool of Medicine$$041369
000007665 7001_ $$aKlick, Mark T.
000007665 8564_ $$9cd7852da-e6a8-4ac2-ba28-c10f13b407bf$$s3027642$$uhttps://digitalcollections.ohsu.edu/record/7665/files/Klick.Mark.2017.pdf
000007665 905__ $$a/rest/prod/js/95/6g/35/js956g35s
000007665 909CO $$ooai:digitalcollections.ohsu.edu:7665$$pstudent-work
000007665 980__ $$aTheses and Dissertations