TY  - GEN
AB  - This dissertation describes the implementation of a technique for using cellular miRNAs as tools for the discovery of virus-host interactions. With this methodology, I discovered a new function for the UPR during DENV2, namely inhibition of innate immune signaling, as well as identifying a miRNA that impedes flavivirus infection in spite of failure to enhance cellular immunity.
AU  - Murphy, Ashleigh R.
DA  - 2017
DO  - 10.6083/m4sx6csd
DO  - DOI
ID  - 7666
KW  - Unfolded Protein Response
KW  - Flavivirus
KW  - MicroRNAs
KW  - Dengue Virus
KW  - innate immunity
L1  - https://digitalcollections.ohsu.edu/record/7666/files/Murphy.Ashleigh.2017.pdf
L2  - https://digitalcollections.ohsu.edu/record/7666/files/Murphy.Ashleigh.2017.pdf
L4  - https://digitalcollections.ohsu.edu/record/7666/files/Murphy.Ashleigh.2017.pdf
LK  - https://digitalcollections.ohsu.edu/record/7666/files/Murphy.Ashleigh.2017.pdf
N2  - This dissertation describes the implementation of a technique for using cellular miRNAs as tools for the discovery of virus-host interactions. With this methodology, I discovered a new function for the UPR during DENV2, namely inhibition of innate immune signaling, as well as identifying a miRNA that impedes flavivirus infection in spite of failure to enhance cellular immunity.
PB  - Oregon Health and Science University
PY  - 2017
T1  - Dengue virus and the suppression of the cellular innate immune response: antiviral microRNAs as a tool for probing host-virus interactions
TI  - Dengue virus and the suppression of the cellular innate immune response: antiviral microRNAs as a tool for probing host-virus interactions
UR  - https://digitalcollections.ohsu.edu/record/7666/files/Murphy.Ashleigh.2017.pdf
Y1  - 2017
ER  -