000007668 001__ 7668
000007668 005__ 20231211095450.0
000007668 0247_ $$2DOI$$a10.6083/m4tq60n9
000007668 037__ $$aETD
000007668 245__ $$aAggregating common, rare, and private variants in Alzheimer's disease genes
000007668 260__ $$bOregon Health and Science University
000007668 269__ $$a2017
000007668 336__ $$aCapstone
000007668 502__ $$bM.B.I.
000007668 520__ $$aAlzheimer's disease (AD) is an irreversible neurodegenerative disorder.  It is the sixth leading cause of death in the United States. Genome-wide association studies have uncovered nearly 40 common genetic variants (minor allele frequency (MAF) > 5%) which are associated with increased susceptibility to AD. However, the common variants found so far do not completely account for the genetic component of the disease. With the technological advancement of deep sequencing, the focus has shifted to exploring the role of rare (MAF < 0.5%) and private variants.
000007668 650__ $$aGenome-Wide Association Study$$038168
000007668 650__ $$aPhenotype$$023948
000007668 650__ $$aAlzheimer Disease$$014513
000007668 650__ $$aLinkage Disequilibrium$$028668
000007668 691__ $$aSchool of Medicine$$041369
000007668 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000007668 7001_ $$aDas, Prerna$$uOregon Health and Science University$$041354
000007668 8564_ $$96f9ddb6c-068f-423a-aedc-21cfbb127982$$s5747116$$uhttps://digitalcollections.ohsu.edu/record/7668/files/Das.Prerna.2017.pdf
000007668 905__ $$a/rest/prod/37/72/0d/21/37720d21t
000007668 909CO $$ooai:digitalcollections.ohsu.edu:7668$$pstudent-work
000007668 980__ $$aTheses and Dissertations