TY  - GEN
N2  - Polymorphonuclear leukocytes, specifically neutrophils, are highly dynamic, multi-functional innate immune cells. Neutrophils are among the first cellular responders to bacterial host tissue infection. At sites of inflammation, neutrophils can undergo activation, releasing their nuclear content to form microbicidal neutrophil extracellular traps (NETs). NETs provide a structural framework for pathogen clearance; however, recent studies have demonstrated that NETs may additionally contribute to thrombotic complications, including deep vein thrombosis. The crosstalk and underlying mechanisms in the blood microenvironment that regulate NETs formation and potentiate thrombus formation remain ill-defined. This gap in knowledge has guided my research thus far, driving investigations into how the blood microenvironment influences neutrophil activation, specifically NETosis, and how the thrombogenic potential of NETs is dynamically regulated.
DO  - 10.6083/m4v1249c
DO  - DOI
AB  - Polymorphonuclear leukocytes, specifically neutrophils, are highly dynamic, multi-functional innate immune cells. Neutrophils are among the first cellular responders to bacterial host tissue infection. At sites of inflammation, neutrophils can undergo activation, releasing their nuclear content to form microbicidal neutrophil extracellular traps (NETs). NETs provide a structural framework for pathogen clearance; however, recent studies have demonstrated that NETs may additionally contribute to thrombotic complications, including deep vein thrombosis. The crosstalk and underlying mechanisms in the blood microenvironment that regulate NETs formation and potentiate thrombus formation remain ill-defined. This gap in knowledge has guided my research thus far, driving investigations into how the blood microenvironment influences neutrophil activation, specifically NETosis, and how the thrombogenic potential of NETs is dynamically regulated.
T1  - Regulation of the innate immune response by the blood coagulation cascade
DA  - 2017
AU  - Healy, Laura D.
L1  - https://digitalcollections.ohsu.edu/record/7669/files/Healy.Laura.2017.pdf
PB  - Oregon Health and Science University
PY  - 2017
ID  - 7669
L4  - https://digitalcollections.ohsu.edu/record/7669/files/Healy.Laura.2017.pdf
KW  - Hematology
KW  - Protein C
KW  - Neutrophils
KW  - Blood Coagulation
KW  - fluorescence microscopy
TI  - Regulation of the innate immune response by the blood coagulation cascade
Y1  - 2017
L2  - https://digitalcollections.ohsu.edu/record/7669/files/Healy.Laura.2017.pdf
LK  - https://digitalcollections.ohsu.edu/record/7669/files/Healy.Laura.2017.pdf
UR  - https://digitalcollections.ohsu.edu/record/7669/files/Healy.Laura.2017.pdf
ER  -