000007669 001__ 7669
000007669 005__ 20240124114249.0
000007669 0247_ $$2DOI$$a10.6083/m4v1249c
000007669 037__ $$aETD
000007669 245__ $$aRegulation of the innate immune response by the blood coagulation cascade
000007669 260__ $$bOregon Health and Science University
000007669 269__ $$a2017
000007669 336__ $$aDissertation
000007669 502__ $$bPh.D.
000007669 520__ $$aPolymorphonuclear leukocytes, specifically neutrophils, are highly dynamic, multi-functional innate immune cells. Neutrophils are among the first cellular responders to bacterial host tissue infection. At sites of inflammation, neutrophils can undergo activation, releasing their nuclear content to form microbicidal neutrophil extracellular traps (NETs). NETs provide a structural framework for pathogen clearance; however, recent studies have demonstrated that NETs may additionally contribute to thrombotic complications, including deep vein thrombosis. The crosstalk and underlying mechanisms in the blood microenvironment that regulate NETs formation and potentiate thrombus formation remain ill-defined. This gap in knowledge has guided my research thus far, driving investigations into how the blood microenvironment influences neutrophil activation, specifically NETosis, and how the thrombogenic potential of NETs is dynamically regulated.
000007669 542__ $$fIn copyright - single owner
000007669 650__ $$aHematology$$020009
000007669 650__ $$aProtein C$$024745
000007669 650__ $$aNeutrophils$$022885
000007669 650__ $$aBlood Coagulation$$015652
000007669 6531_ $$afluorescence microscopy
000007669 691__ $$aSchool of Medicine$$041369
000007669 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000007669 7001_ $$aHealy, Laura D.
000007669 8564_ $$9b8aa0ff8-b994-465f-9b74-fb7c22f5904f$$s3027501$$uhttps://digitalcollections.ohsu.edu/record/7669/files/Healy.Laura.2017.pdf
000007669 905__ $$a/rest/prod/d2/17/qq/13/d217qq13n
000007669 909CO $$ooai:digitalcollections.ohsu.edu:7669$$pstudent-work
000007669 980__ $$aTheses and Dissertations