TY  - GEN
N2  - This dissertation presents novel evidence that PTPN11 is activated by an upstream kinase, TNK2. PTPN11-mutant JMML and AML primary patient cells have displayed significant sensitivity to TNK2 inhibition by dasatinib. My research has revealed that PTPN11 and TNK2 interact directly, allowing for TNK2 dependent phosphorylation of PTPN11.
DO  - 10.6083/m4wd404b
DO  - DOI
AB  - This dissertation presents novel evidence that PTPN11 is activated by an upstream kinase, TNK2. PTPN11-mutant JMML and AML primary patient cells have displayed significant sensitivity to TNK2 inhibition by dasatinib. My research has revealed that PTPN11 and TNK2 interact directly, allowing for TNK2 dependent phosphorylation of PTPN11.
T1  - Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia
DA  - 2017
AU  - Jenkins, Chelsea
L1  - https://digitalcollections.ohsu.edu/record/7676/files/Jenkins.Chelsea.2017.pdf
PB  - Oregon Health and Science University
PY  - 2017
ID  - 7676
L4  - https://digitalcollections.ohsu.edu/record/7676/files/Jenkins.Chelsea.2017.pdf
KW  - Leukemia
KW  - Mitogen-Activated Protein Kinases
KW  - Dasatinib
KW  - human
KW  - tnk2 protein
KW  - ptpn11 protein
TI  - Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia
Y1  - 2017
L2  - https://digitalcollections.ohsu.edu/record/7676/files/Jenkins.Chelsea.2017.pdf
LK  - https://digitalcollections.ohsu.edu/record/7676/files/Jenkins.Chelsea.2017.pdf
UR  - https://digitalcollections.ohsu.edu/record/7676/files/Jenkins.Chelsea.2017.pdf
ER  -