000007676 001__ 7676
000007676 005__ 20240124114249.0
000007676 0247_ $$2DOI$$a10.6083/m4wd404b
000007676 037__ $$aETD
000007676 245__ $$aSynthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia
000007676 260__ $$bOregon Health and Science University
000007676 269__ $$a2017
000007676 336__ $$aDissertation
000007676 502__ $$bPh.D.
000007676 520__ $$aThis dissertation presents novel evidence that PTPN11 is activated by an upstream kinase, TNK2. PTPN11-mutant JMML and AML primary patient cells have displayed significant sensitivity to TNK2 inhibition by dasatinib. My research has revealed that PTPN11 and TNK2 interact directly, allowing for TNK2 dependent phosphorylation of PTPN11.
000007676 542__ $$fIn copyright - single owner
000007676 650__ $$aLeukemia$$021430
000007676 650__ $$aMitogen-Activated Protein Kinases$$032817
000007676 650__ $$aDasatinib$$011399
000007676 6531_ $$ahuman
000007676 6531_ $$atnk2 protein
000007676 6531_ $$aptpn11 protein
000007676 691__ $$aSchool of Medicine$$041369
000007676 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000007676 7001_ $$aJenkins, Chelsea
000007676 8564_ $$9a5a2abe4-c894-4030-bcda-f3c69685ad65$$s17334620$$uhttps://digitalcollections.ohsu.edu/record/7676/files/Jenkins.Chelsea.2017.pdf
000007676 905__ $$a/rest/prod/wh/24/6s/73/wh246s730
000007676 909CO $$ooai:digitalcollections.ohsu.edu:7676$$pstudent-work
000007676 980__ $$aTheses and Dissertations