000007685 001__ 7685
000007685 005__ 20231129124929.0
000007685 0247_ $$2DOI$$a10.6083/m42v2f7b
000007685 037__ $$aETD
000007685 245__ $$aAugmenting combination immunotherapies with vaccination or costimulatory/inhibitory antibodies for the treatment of cancer
000007685 260__ $$bMarylhurst University: Oregon Health and Science University
000007685 269__ $$a2016
000007685 336__ $$aThesis
000007685 502__ $$bPh.D.
000007685 520__ $$aThe human immune system’s relationship with cancer is incredibly complex. However, suggestions that the immune system can treat cancer have kept scientists searching for potential ways to augment immunity for over 100 years. We hypothesize that overcoming immune tolerance and activating a functional anti-tumor T cell response in cancer patients requires sufficient antigenic targets, tumor-specific primed T cells, the proper costimulatory signals, and the right cytokine milieu.
000007685 650__ $$aImmunotherapy $$020724
000007685 650__ $$aAntibodies$$014849
000007685 650__ $$aVaccines $$027692
000007685 650__ $$aNeoplasms $$022758
000007685 691__ $$aSchool of Medicine$$041369
000007685 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000007685 7001_ $$aMessenheimer, David J.
000007685 8564_ $$98c80e489-22c1-40ae-ab42-9005d97b1e8d$$s29185259$$uhttps://digitalcollections.ohsu.edu/record/7685/files/Messenheimer.David.2016.pdf
000007685 905__ $$a/rest/prod/b2/77/3w/18/b2773w18h
000007685 909CO $$ooai:digitalcollections.ohsu.edu:7685$$pstudent-work
000007685 980__ $$aTheses and Dissertations