000000769 001__ 769
000000769 005__ 20251217152928.0
000000769 0247_ $$2DOI$$a10.6083/M47P8WD2
000000769 037__ $$aETD
000000769 245__ $$aMolecular targeting of translesion synthesis DNA polymerases for novel combination chemotherapy
000000769 260__ $$bOregon Health and Science University
000000769 269__ $$a2012
000000769 336__ $$aDissertation
000000769 502__ $$bPh.D.
000000769 502__ $$gPhysiology & Pharmacology (sunsetting)
000000769 520__ $$aGenomic DNA is constantly exposed to damaging agents, leading to diverse lesions. Cells employ repair and tolerance mechanisms, including translesion DNA synthesis (TLS), mediated by specialized polymerases. TLS can prevent cancer by accurate lesion bypass but may also promote carcinogenesis and chemoresistance through error-prone replication. This dissertation investigates TLS polymerase functions, focusing on newly discovered polymerase ν, identifies polymerases processing DNA–peptide cross-links, and explores polymerase κ as a therapeutic target by screening small-molecule inhibitors. Findings advance understanding of TLS in cancer development and resistance, offering strategies for novel combination therapies.
000000769 540__ $$fCC BY
000000769 542__ $$fIn copyright - single owner
000000769 650__ $$aNucleic Acids$$023049
000000769 650__ $$aHigh-Throughput Screening Assays$$038869
000000769 650__ $$aDNA Replication$$017991
000000769 650__ $$aNucleic Acid Synthesis Inhibitors$$031587
000000769 650__ $$aDNA-Directed DNA Polymerase$$017989
000000769 650__ $$aDNA Repair$$017990
000000769 650__ $$aNeoplasms$$022758
000000769 650__ $$aDrug Development$$012608
000000769 650__ $$aDNA$$017977
000000769 650__ $$aDrug Resistance, Neoplasm$$031278
000000769 650__ $$aTranslesion DNA Synthesis
000000769 650__ $$aCarcinogenesis$$040251
000000769 6531_ $$atranslesion synthesis
000000769 6531_ $$adna interstrand cross-links
000000769 6531_ $$acancer
000000769 6531_ $$adna-peptide cross-links
000000769 691__ $$aSchool of Medicine$$041369
000000769 692__ $$aDepartment of Physiology and Pharmacology$$041442
000000769 7001_ $$aYamanaka, Kinrin$$uOregon Health and Science University$$041354
000000769 7201_ $$aLloyd, Stephen$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000769 8564_ $$9bd8d00ee-3e73-40a1-9a3a-ac64b163a302$$s2842733$$uhttps://digitalcollections.ohsu.edu/record/769/files/772_etd.pdf$$ePublic$$2a07078493fdc77029e150189fd0d48ee$$31
000000769 905__ $$a/rest/prod/5q/47/rn/75/5q47rn75s
000000769 909CO $$ooai:digitalcollections.ohsu.edu:769$$pstudent-work
000000769 980__ $$aTheses and Dissertations