TY  - GEN
AB  - Rat sarcoma viral oncogene homolog (Ras) proteins are important signaling molecules ubiquitously expressed in eukaryotes and are key regulators of normal proliferation and differentiation. The Ras family is a group of small GTPases that reside on the membrane and are involved in multiple cell signaling cascades.They transmit growth signals from cell surface receptors, such as tyrosine kinase receptors, by switching between GTP or GDP bound states. Ras is inactive when GDP bound, but stimulation by upstream factors results in the exchange of GDP for GTP with the aid of guanine exchange factors (GEFs). GTP bound Ras is able to bind and recruit downstream electors to the membrane. Although Ras is able to hydrolyze GTP to GDP, the endogenous reaction is slow and is catalyzed by GTPase-activating proteins (GAPs). A third of all human cancers have a constitutively active Ras mutation, making Ras one of the most frequently mutated oncogenes. Oncogenic Ras mutations are single base substitutions that stabilize GTP-bound state which results in constitutive activation of Ras and its target proteins, leading to several hallmarks of cancer.
AU  - Lee, Yerim
DA  - 2019
DO  - 10.6083/3t945r47j
DO  - DOI
ID  - 7715
KW  - Microscopy
KW  - ras Proteins
KW  - Signal Transduction
KW  - Diffusion
L1  - https://digitalcollections.ohsu.edu/record/7715/files/lee.yerim.2019.pdf
L2  - https://digitalcollections.ohsu.edu/record/7715/files/lee.yerim.2019.pdf
L4  - https://digitalcollections.ohsu.edu/record/7715/files/lee.yerim.2019.pdf
LK  - https://digitalcollections.ohsu.edu/record/7715/files/lee.yerim.2019.pdf
N2  - Rat sarcoma viral oncogene homolog (Ras) proteins are important signaling molecules ubiquitously expressed in eukaryotes and are key regulators of normal proliferation and differentiation. The Ras family is a group of small GTPases that reside on the membrane and are involved in multiple cell signaling cascades.They transmit growth signals from cell surface receptors, such as tyrosine kinase receptors, by switching between GTP or GDP bound states. Ras is inactive when GDP bound, but stimulation by upstream factors results in the exchange of GDP for GTP with the aid of guanine exchange factors (GEFs). GTP bound Ras is able to bind and recruit downstream electors to the membrane. Although Ras is able to hydrolyze GTP to GDP, the endogenous reaction is slow and is catalyzed by GTPase-activating proteins (GAPs). A third of all human cancers have a constitutively active Ras mutation, making Ras one of the most frequently mutated oncogenes. Oncogenic Ras mutations are single base substitutions that stabilize GTP-bound state which results in constitutive activation of Ras and its target proteins, leading to several hallmarks of cancer.
PB  - Marylhurst University: Oregon Health and Science University
PY  - 2019
T1  - Probing the spatiotemporal dynamics of Ras GTPases on the cell membrane with high-throughput single-molecule microscopy
TI  - Probing the spatiotemporal dynamics of Ras GTPases on the cell membrane with high-throughput single-molecule microscopy
UR  - https://digitalcollections.ohsu.edu/record/7715/files/lee.yerim.2019.pdf
Y1  - 2019
ER  -