TY  - GEN
N2  - Mycobacterium tuberculosis (Mtb) is the etiologic pathogen of tuberculosis (TB), the leading infectious cause of death. Mtb is a diderm bacillus that is exquisitely well-adapted to its human host. In this work, we identify the lipoprotein LpqN as a periplasmic interacting partner of the mycolate transporters MmpL3 and MmpL11, and of secreted mycolyltransferases. Together, this work furthers our understanding of the bacterial physiology underlying the biogenesis of the mycobacterial cell envelope, perhaps the most critical interface between the host and pathogen.
DO  - 10.6083/3484zh63z
DO  - DOI
AB  - Mycobacterium tuberculosis (Mtb) is the etiologic pathogen of tuberculosis (TB), the leading infectious cause of death. Mtb is a diderm bacillus that is exquisitely well-adapted to its human host. In this work, we identify the lipoprotein LpqN as a periplasmic interacting partner of the mycolate transporters MmpL3 and MmpL11, and of secreted mycolyltransferases. Together, this work furthers our understanding of the bacterial physiology underlying the biogenesis of the mycobacterial cell envelope, perhaps the most critical interface between the host and pathogen.
T1  - Characterization of membrane-associated proteins involved in mycobacterium tuberculosis cell envelope biogenesis
DA  - 2019
AU  - Melly, Geoff
L1  - https://digitalcollections.ohsu.edu/record/7716/files/Melly.Geoff.2019.pdf
PB  - Marylhurst University: Oregon Health and Science University
PY  - 2019
ID  - 7716
L4  - https://digitalcollections.ohsu.edu/record/7716/files/Melly.Geoff.2019.pdf
KW  - Virulence
KW  - Lipids
KW  - Mycobacterium tuberculosis
KW  - Lipoproteins
KW  - cell envelope
TI  - Characterization of membrane-associated proteins involved in mycobacterium tuberculosis cell envelope biogenesis
Y1  - 2019
L2  - https://digitalcollections.ohsu.edu/record/7716/files/Melly.Geoff.2019.pdf
LK  - https://digitalcollections.ohsu.edu/record/7716/files/Melly.Geoff.2019.pdf
UR  - https://digitalcollections.ohsu.edu/record/7716/files/Melly.Geoff.2019.pdf
ER  -