000007716 001__ 7716
000007716 005__ 20240124114250.0
000007716 0247_ $$2DOI$$a10.6083/3484zh63z
000007716 037__ $$aETD
000007716 245__ $$aCharacterization of membrane-associated proteins involved in mycobacterium tuberculosis cell envelope biogenesis
000007716 260__ $$bMarylhurst University: Oregon Health and Science University
000007716 269__ $$a2019
000007716 336__ $$aDissertation
000007716 502__ $$bPh.D.
000007716 520__ $$aMycobacterium tuberculosis (Mtb) is the etiologic pathogen of tuberculosis (TB), the leading infectious cause of death. Mtb is a diderm bacillus that is exquisitely well-adapted to its human host. In this work, we identify the lipoprotein LpqN as a periplasmic interacting partner of the mycolate transporters MmpL3 and MmpL11, and of secreted mycolyltransferases. Together, this work furthers our understanding of the bacterial physiology underlying the biogenesis of the mycobacterial cell envelope, perhaps the most critical interface between the host and pathogen.
000007716 542__ $$fIn copyright - single owner
000007716 650__ $$aVirulence$$027844
000007716 650__ $$aLipids$$021539
000007716 650__ $$aMycobacterium tuberculosis$$022570
000007716 650__ $$aLipoproteins$$021556
000007716 6531_ $$acell envelope
000007716 691__ $$aSchool of Medicine$$041369
000007716 7001_ $$aMelly, Geoff
000007716 8564_ $$944db33be-f2c7-42dd-805e-692f49d0639a$$s18570813$$uhttps://digitalcollections.ohsu.edu/record/7716/files/Melly.Geoff.2019.pdf
000007716 905__ $$a/rest/prod/34/84/zh/63/3484zh63z
000007716 909CO $$ooai:digitalcollections.ohsu.edu:7716$$pstudent-work
000007716 980__ $$aTheses and Dissertations