000007723 001__ 7723
000007723 005__ 20240124114250.0
000007723 0247_ $$2DOI$$a10.6083/g445cd61z
000007723 037__ $$aETD
000007723 041__ $$aeng
000007723 245__ $$aTriheptanoin supplementation in long-chain fatty acid oxidation disorder patients
000007723 260__ $$bOregon Health and Science University
000007723 269__ $$a2019
000007723 336__ $$aThesis
000007723 502__ $$bM.S.
000007723 502__ $$gHuman Nutrition
000007723 520__ $$aThe overall goal of this project is to conduct a sub-analysis of the primary study data to identify factors related to the magnitude of change from baseline with C7 supplementation. I will analyze the data by LC-FAO disorder diagnosis and compare those supplemented with triheptanoin (C7) versus trioctanoin (C8) to determine if any LC-FAOD had a greater response with C7 supplementation compared to C8 supplementation. Age at initial presentation was recorded and will be used as an estimate of disease severity.  In the original study, all subjects were counseled to consume 20% of their estimated total energy needs daily from C7 or C8 oil for a 4-month period while following a diet low in long-chain fats. Adherence was assessed by multiple 3-day diet records and measurement of unconsumed daily oil at the end of the study. I hypothesize that participants with a more severe phenotype and those who consumed more of the prescribed C7 will have shown a greater response.
000007723 540__ $$fCC BY
000007723 542__ $$fIn copyright - single owner
000007723 6531_ $$avlcad deficiency
000007723 6531_ $$acpt2 deficiency
000007723 6531_ $$alchad deficiency
000007723 6531_ $$atriheptanoin
000007723 691__ $$aSchool of Medicine$$041369
000007723 692__ $$aGraduate Programs in Human Nutrition$$041470
000007723 7001_ $$aBrown, Georgia$$uOregon Health and Science University$$041354
000007723 8564_ $$98605f008-25df-478e-8e54-88cd7cc36acc$$s1861316$$uhttps://digitalcollections.ohsu.edu/record/7723/files/Brown.Georgia.2019.pdf
000007723 905__ $$a/rest/prod/m3/26/m2/26/m326m226h
000007723 909CO $$ooai:digitalcollections.ohsu.edu:7723$$pstudent-work
000007723 980__ $$aTheses and Dissertations