000000773 001__ 773
000000773 005__ 20260120144838.0
000000773 0247_ $$2DOI$$a10.6083/M4QN64RP
000000773 037__ $$aETD
000000773 245__ $$aThe subtype specific roles of SK2 and SK3 channels in dopamine neurons of the substantia nigra
000000773 260__ $$bOregon Health and Science University
000000773 269__ $$a2012
000000773 336__ $$aDissertation
000000773 502__ $$bPh.D.
000000773 502__ $$gNeuroscience
000000773 520__ $$aDopamine neurons in the substantia nigra (SN) are strongly regulated by small-conductance calcium-activated potassium (SK) channels, previously attributed solely to SK3 expression. We demonstrate that SK2 is also present in SN dopamine neurons and is selectively localized to distal dendrites, unlike the uniform distribution of SK3. Pharmacological blockade of SK2 reduced the regularity of pacemaker activity without altering firing frequency. Unlike other cell types, dendritic SK2 in dopamine neurons did not influence fast glutamatergic synaptic transmission. These findings reveal a distinct role for SK2 in shaping dendritic excitability and pacemaking in SN dopamine neurons.
000000773 540__ $$fCC BY
000000773 542__ $$fIn copyright - single owner
000000773 650__ $$aDopaminergic Neurons$$039537
000000773 650__ $$aSubstantia Nigra$$026530
000000773 650__ $$aSmall-Conductance Calcium-Activated Potassium Channels$$036935
000000773 650__ $$aSynaptic Transmission$$022820
000000773 650__ $$aCalcium, Dietary$$015980
000000773 6531_ $$acalcium-dependent potassium channels
000000773 6531_ $$ask channels
000000773 6531_ $$aneural transmission
000000773 691__ $$aSchool of Medicine$$041369
000000773 692__ $$aVollum Institute$$041509
000000773 7001_ $$aDeignan, Jason$$uOregon Health and Science University$$041354
000000773 7201_ $$aAdelman, John$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000773 8564_ $$91349d332-40c1-4047-ab94-795757015661$$s9855690$$uhttps://digitalcollections.ohsu.edu/record/773/files/776_etd.pdf$$ePublic$$289644df9dfb1937458390fb719df2ec8$$31
000000773 905__ $$a/rest/prod/8k/71/nh/10/8k71nh10x
000000773 909CO $$ooai:digitalcollections.ohsu.edu:773$$pstudent-work
000000773 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000773 980__ $$aTheses and Dissertations