000007731 001__ 7731
000007731 005__ 20231129124938.0
000007731 0247_ $$2DOI$$a10.6083/y7ax-xc61
000007731 037__ $$aETD
000007731 245__ $$aToward a durable, small diameter tissue engineered vascular graft: understanding the utility of surface micropatterning and maximizing the value of real-time ex vivo thrombosis testing
000007731 260__ $$bMarylhurst University: Oregon Health and Science University
000007731 269__ $$a2019
000007731 336__ $$aDissertation
000007731 502__ $$bPh.D.
000007731 520__ $$aDurable artificial small-diameter vascular grafts are a critical unmet need in a medical landscape where advanced cardiovascular diseases remain the leading causes of morbidity and mortality. As classical approaches based on maximizing biomaterial inertness have failed to overcome the thrombosis and hyperplasia that drive device failure, novel solutions inspired by the function of the native endothelium are necessary. Biomaterial devices designed for rapid in vitro or in situ endothelialization, and devices designed to mimic endothelial function are all active areas of study which will be addressed within this dissertation. Endothelial colony forming cells are an incompletely understood blood outgrowth product with tremendous potential for tissue engineering applications. This dissertation includes the novel characterization of the sensitivity of these cells to flow-independent morphological modulations, which will add to the understanding of their suitability for use in tissue engineered grafts.
000007731 542__ $$fIn copyright - single owner
000007731 650__ $$aEndothelial Cells$$035222
000007731 650__ $$aEndothelial Progenitor Cells$$040757
000007731 650__ $$aTissue Engineering$$033051
000007731 650__ $$aCardiovascular Diseases$$016152
000007731 650__ $$aThrombosis$$027034
000007731 650__ $$aBiocompatible Materials$$015550
000007731 691__ $$aSchool of Medicine$$041369
000007731 692__ $$aDepartment of Biomedical Engineering$$041397
000007731 7001_ $$aHagen, Matthew W.
000007731 8564_ $$99c4def4c-e718-48a8-abf4-5e813d17fb44$$s6018854$$uhttps://digitalcollections.ohsu.edu/record/7731/files/Hagen.Matt.2019.pdf
000007731 905__ $$a/rest/prod/wm/11/7p/68/wm117p68c
000007731 909CO $$ooai:digitalcollections.ohsu.edu:7731$$pstudent-work
000007731 980__ $$aTheses and Dissertations