000007732 001__ 7732
000007732 005__ 20240124114251.0
000007732 0247_ $$2DOI$$a10.6083/g12q-ew77
000007732 037__ $$aETD
000007732 245__ $$aStructure and function of the epithelial sodium channel
000007732 260__ $$bMarylhurst University: Oregon Health and Science University
000007732 269__ $$a2020
000007732 336__ $$aDissertation
000007732 502__ $$bPh.D.
000007732 520__ $$aThe epithelial sodium channel (ENaC) is expressed at the apical side of epithelial cells and is a key regulator of salt and water balance. By serving as the rate-limiting step of sodium reabsorption in the aldosterone sensitive distal nephron of the kidneys, ENaC regulates blood volume and thereby modulates blood pressure. ENaC is an obligate heterotrimeric ion channel comprised of three homologous subunits, a, b, g, and belongs to the ENaC/degenerin superfamily, known to be voltage independent, sodium selective and sensitive to the small molecule amiloride. Members of this superfamily have short intracellular N- and C-termini, two membrane-spanning a-helical segments, and a large extracellular domain (ECD). The gating of ENaC is highly unusual for an ion channel, whereby the a and g subunits are cleaved at distinct extracellular sites by proteases causing release of inhibitory peptides to activate the receptor and open the channel. Another unique property of the ENaC channel includes a high selectivity for sodium over potassium at 100:1 compared to 30-3:1 for acid sensing ion channels, another member in the same superfamily.
000007732 542__ $$fIn copyright - single owner
000007732 650__ $$aCryoelectron Microscopy$$032293
000007732 650__ $$aIon Channels$$021013
000007732 650__ $$aKidney$$021185
000007732 650__ $$aEpithelial Sodium Channels$$037426
000007732 650__ $$aHypertension$$020538
000007732 6531_ $$aenac (epithelial na+ channel)
000007732 691__ $$aSchool of Medicine$$041369
000007732 692__ $$aDepartment of Biochemistry and Molecular Biology$$041396
000007732 7001_ $$aNoreng, Sigrid
000007732 8564_ $$95440d880-8dc4-47ee-9232-ee4ed04d2f06$$s26259993$$uhttps://digitalcollections.ohsu.edu/record/7732/files/Noreng.Sigrid.2020.pdf
000007732 905__ $$a/rest/prod/ff/36/55/97/ff365597g
000007732 909CO $$ooai:digitalcollections.ohsu.edu:7732$$pstudent-work
000007732 980__ $$aTheses and Dissertations