@article{ETD,
      recid = {776},
      author = {Iles-Shih, Matthew},
      title = {Evaluation of mycobacterium tuberculosis antigen-specific  CD8+T cell responses},
      publisher = {Oregon Health and Science University},
      school = {M.P.H.},
      address = {2012},
      number = {ETD},
      abstract = {CD8+ T cells are critical in controlling Mycobacterium  tuberculosis (Mtb) infection, yet their role in  distinguishing active TB (ATB) from latent infection (LTBI)  remains unclear. We evaluated IFN-γ CD8+ T cell responses  to five novel Mtb antigens in 108 TB-positive subjects from  Uganda using ELISPOT. While categorical response thresholds  showed no significant association with TB phenotype,  quantitative analysis revealed significantly higher IFN-γ  responses to four antigens in ATB versus LTBI (p ≤ 0.015).  These findings suggest continuous CD8+ T cell IFN-γ  responses correlate with bacillary burden and may inform TB  diagnostics and vaccine development.},
      url = {http://digitalcollections.ohsu.edu/record/776},
      doi = {https://doi.org/10.6083/M4BG2M0Z},
}