@article{ETD,
      recid = {782},
      author = {Triplett, Todd},
      title = {Identification of a novel human CD4+ T cell population and  overcoming the immunosuppressive environment in large  established tumors},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2012},
      number = {ETD},
      abstract = {T cell function is regulated by cytokines and receptor  expression, notably IL-2 and CD25. While murine CD25  expression is largely restricted to Tregs, humans exhibit a  CD25^low/intermediate FOXP3^– memory subset previously  thought to be recently activated. We show this population  is quiescent, phenotypically distinct from CD25^– memory  cells, and differentially affected by IL-2 therapy in  cancer patients, with no murine equivalent—highlighting  translational limitations. Additionally, we demonstrate  that combining OX40 agonist therapy with TGF-β receptor  inhibition eradicates large tumors in mice, enhancing CD8+  T cell proliferation and function. These findings inform  IL-2/CD25-targeted therapies and novel cancer immunotherapy  strategies.},
      url = {http://digitalcollections.ohsu.edu/record/782},
      doi = {https://doi.org/10.6083/M4K0729M},
}