000000782 001__ 782
000000782 005__ 20260120144838.0
000000782 0247_ $$2DOI$$a10.6083/M4K0729M
000000782 037__ $$aETD
000000782 245__ $$aIdentification of a novel human CD4+ T cell population and overcoming the immunosuppressive environment in large established tumors
000000782 260__ $$bOregon Health and Science University
000000782 269__ $$a2012
000000782 336__ $$aDissertation
000000782 502__ $$bPh.D.
000000782 520__ $$aT cell function is regulated by cytokines and receptor expression, notably IL-2 and CD25. While murine CD25 expression is largely restricted to Tregs, humans exhibit a CD25^low/intermediate FOXP3^– memory subset previously thought to be recently activated. We show this population is quiescent, phenotypically distinct from CD25^– memory cells, and differentially affected by IL-2 therapy in cancer patients, with no murine equivalent—highlighting translational limitations. Additionally, we demonstrate that combining OX40 agonist therapy with TGF-β receptor inhibition eradicates large tumors in mice, enhancing CD8+ T cell proliferation and function. These findings inform IL-2/CD25-targeted therapies and novel cancer immunotherapy strategies.
000000782 540__ $$fCC BY
000000782 542__ $$fIn copyright - single owner
000000782 650__ $$aImmunotherapy$$020724
000000782 650__ $$aInterleukin-2$$020918
000000782 650__ $$aT-Lymphocytes$$026731
000000782 650__ $$aCD4-Positive T-Lymphocytes$$028453
000000782 650__ $$aTransforming Growth Factor beta$$028969
000000782 650__ $$aMice$$036842
000000782 650__ $$aNeoplasms$$022758
000000782 691__ $$aSchool of Medicine$$041369
000000782 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000000782 7001_ $$aTriplett, Todd$$uOregon Health and Science University$$041354
000000782 7201_ $$aWeinberg, Andrew$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000782 8564_ $$9feca6430-4f4c-42c9-832f-e66e4a30c9ab$$s3133585$$uhttps://digitalcollections.ohsu.edu/record/782/files/785_etd.pdf$$ePublic$$2036dbaa1a6ce6ff8f100412f8c230d7c$$31
000000782 905__ $$a/rest/prod/69/69/z0/80/6969z080f
000000782 909CO $$ooai:digitalcollections.ohsu.edu:782$$pstudent-work
000000782 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000782 980__ $$aTheses and Dissertations