000007841 001__ 7841
000007841 005__ 20251105111642.0
000007841 0247_ $$2DOI$$a10.6083/M4Z03767
000007841 037__ $$aETD
000007841 245__ $$aGene regulation of the hypothalamic arcuate nucleus during development and postnatal energy balance
000007841 260__ $$bOregon Health and Science University
000007841 269__ $$a2015
000007841 336__ $$aDissertation
000007841 502__ $$bPh.D.
000007841 520__ $$aWe have witnessed a dramatic expansion of metabolic pathologies including  obesity, diabetes, and cardiovascular diseases during the last several decades.  The fundamental cause of obesity and many metabolic disorders is an energy  imbalance between caloric input and energy output. Here we present our discoveries that reveal two key molecular mechanisms for how the expression of the orexigenic neuropeptides,  AgRP and NPY, are controlled, and also identify a critical transcription factor (Isl1) that regulates embryonic development of various arcuate neuronal cell types.
000007841 542__ $$fIn copyright - single owner
000007841 650__ $$aHypothalamus$$020595
000007841 650__ $$aTranscription Factors$$027255
000007841 650__ $$aReceptors, Glucocorticoid$$025200
000007841 650__ $$aArcuate Nucleus of Hypothalamus$$015041
000007841 691__ $$aSchool of Medicine$$041369
000007841 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000007841 7001_ $$aLee, Bora$$uOregon Health and Science University$$041354
000007841 7201_ $$aLee, Jae$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000007841 8564_ $$9f79f23ff-86d4-449d-ab84-8500f0930369$$s4921249$$uhttps://digitalcollections.ohsu.edu/record/7841/files/lee.bora.2016.pdf$$ePublic$$24a6c80b15c18bb6c6e5d7b973fcea978$$31
000007841 905__ $$a/rest/prod/n2/96/wz/75/n296wz75w
000007841 909CO $$ooai:digitalcollections.ohsu.edu:7841$$pstudent-work
000007841 980__ $$aTheses and Dissertations