TY - GEN AB - The transcription factor Olig2 is essential for the specification of neurons and oligodendrocytes, as well as a subset of astrocytes during both neural tube and telencephalon development. Yet, how this single transcription factor is capable of generating these disparate cell types has remained largely unknown. This work elucidates multiple mechanisms, including temporal phosphorylation and dimerization partner choice, which govern the developmental action of Olig2. AD - Oregon Health and Science University AU - Harrold, Alexandria DA - 2015 DO - 10.6083/M4C53JVX DO - DOI ED - Lee, Soo-Kyung ED - Mentor ID - 7856 KW - Spinal Cord KW - Astrocytes KW - Transcription Factors L1 - https://digitalcollections.ohsu.edu/record/7856/files/Harrold.Alexandria.2015.pdf L2 - https://digitalcollections.ohsu.edu/record/7856/files/Harrold.Alexandria.2015.pdf L4 - https://digitalcollections.ohsu.edu/record/7856/files/Harrold.Alexandria.2015.pdf LK - https://digitalcollections.ohsu.edu/record/7856/files/Harrold.Alexandria.2015.pdf N2 - The transcription factor Olig2 is essential for the specification of neurons and oligodendrocytes, as well as a subset of astrocytes during both neural tube and telencephalon development. Yet, how this single transcription factor is capable of generating these disparate cell types has remained largely unknown. This work elucidates multiple mechanisms, including temporal phosphorylation and dimerization partner choice, which govern the developmental action of Olig2. PB - Oregon Health and Science University PY - 2015 T1 - Complex regulation of Olig2 activity during spinal cord development TI - Complex regulation of Olig2 activity during spinal cord development UR - https://digitalcollections.ohsu.edu/record/7856/files/Harrold.Alexandria.2015.pdf Y1 - 2015 ER -