000007869 001__ 7869
000007869 005__ 20250424233301.0
000007869 0247_ $$2DOI$$a10.6083/M4VQ31SP
000007869 037__ $$aETD
000007869 245__ $$aModeling the mammalian ovary: a cell-based computational model of early ovarian development in mice and preliminary data for a model of folliculogenesis in Rhesus monkeys.
000007869 260__ $$bOregon Health and Science University
000007869 269__ $$a2016-08-01
000007869 336__ $$aThesis
000007869 502__ $$bM.S.
000007869 520__ $$aProper development and function of the ovary is vital for female mammalian  reproduction. The development of the ovary plays an important role in the formation of the  ovarian follicle reserve, which governs the female reproductive lifespan. One of the main  functions in the developed ovary is the maturation of ovarian follicles, a process known  as folliculogenesis. Exposure to reproductive toxicants and reproductive diseases can  cause adverse reproductive outcomes, possibly leading to infertility. The  purpose of this thesis was to construct a model of early ovarian development, spanning  the origin of primordial germ cells to the formation of primordial follicles, in mice and to gather  data to be used for the development of a model of the preantral stages of folliculogenesis,  the generation of secondary follicles from primordial follicles, in rhesus macaque.
000007869 650__ $$aMice$$036842
000007869 650__ $$aOvary$$023388
000007869 650__ $$aCell Movement$$016289
000007869 650__ $$aMice$$036842
000007869 650__ $$aGerm Cells$$019499
000007869 650__ $$aComputer Simulation$$016989
000007869 650__ $$aInfertility, Female$$020798
000007869 650__ $$aReproduction$$025329
000007869 650__ $$aOvary$$023388
000007869 650__ $$aMacaca mulatta$$021724
000007869 691__ $$aSchool of Medicine$$041369
000007869 692__ $$aInstitute of Environmental Health$$041473
000007869 7001_ $$aWear, Hannah$$uOregon Health and Science University$$041354$$10000-0001-7430-4101
000007869 7201_ $$aWatanabe, Karen$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000007869 8564_ $$9259f2798-4d5a-42f5-95ac-b1f07a57fbb2$$s19284211$$uhttps://digitalcollections.ohsu.edu/record/7869/files/wear.hannah.2016.pdf$$ePublic$$26b76b197fed8e79bde3816a4e237a54f$$31
000007869 905__ $$a/rest/prod/8k/71/nh/80/8k71nh80m
000007869 909CO $$ooai:digitalcollections.ohsu.edu:7869$$pstudent-work
000007869 980__ $$aTheses and Dissertations