000007870 001__ 7870
000007870 005__ 20250424233302.0
000007870 0247_ $$2DOI$$a10.6083/M4WQ02WM
000007870 037__ $$aETD
000007870 245__ $$aGene signatures involved in pathways of head and neck squamous cell carcinoma with higher progression rate
000007870 260__ $$bOregon Health and Science University
000007870 269__ $$a2016-09-01
000007870 336__ $$aThesis
000007870 502__ $$bM.S.
000007870 502__ $$gBiomedical Informatics and Computational Biology
000007870 520__ $$aHead and neck squamous cell carcinoma (HNSCC) is known to have a high progression rate in certain subpopulations, despite existing treatment methods. Due to the lack of significant symptoms, many patients are diagnosed at later stages (III-IV TNM), which provides a limited timeframe for therapeutic decision-making and treatment. The heterogeneity of behavioral risk factors associated with HNSCC, such as smoking and alcohol consumption, along with tumors arising in various anatomical locations, makes reliable stratification of this cancer extremely challenging. Given the complex nature of this cancer in subpopulations that exhibit rapid progression, the aim is to control progression and administer therapy over the longest possible duration in the least invasive manner. To achieve this objective, we focus on identifying targets related to the mechanisms of high progression rates in HNSCC subpopulations by extracting measured gene signatures and driver genes involved in a range of gene regulation patterns.
000007870 542__ $$fIn copyright - single owner
000007870 650__ $$aBase Sequence$$015378
000007870 650__ $$aSquamous Cell Carcinoma of Head and Neck$$012663
000007870 650__ $$aRisk Factors$$025522
000007870 650__ $$aSmoking$$026083
000007870 650__ $$aAlcohol Drinking$$014403
000007870 650__ $$aHead and Neck Neoplasms$$019866
000007870 650__ $$aSquamous Cell Carcinoma of Head and Neck$$012663
000007870 691__ $$aSchool of Medicine$$041369
000007870 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000007870 7001_ $$aSanati, Nasim$$uOregon Health and Science University$$041354$$10000-0001-6681-0418
000007870 7201_ $$aMcWeeney, Shannon$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000007870 8564_ $$911a47571-c712-48a7-9ca7-e002fc2b03e9$$s7236170$$uhttps://digitalcollections.ohsu.edu/record/7870/files/sanati.nasim.2016.pdf$$ePublic$$28b42cecbb80383f363d03b5b05a50dc5$$31
000007870 905__ $$a/rest/prod/d7/91/sg/70/d791sg70h
000007870 909CO $$ooai:digitalcollections.ohsu.edu:7870$$pstudent-work
000007870 980__ $$aTheses and Dissertations