TY  - THES
AB  - The human placenta is the primary life-support organ for the developing fetus. It integrates a multi-organ system's functions but comprises only five major cell types. It is a highly metabolic organ, consuming 40% of the total oxygen used by the entire conceptus while accounting for only 20% of its total mass. This high metabolic activity supports the placenta’s extensive transport function, its manufacture of hormones, and the biochemical processing of nutrients. The precise functions of the cells within the placenta that underlie these processes remain poorly defined. This thesis reports that some of the metabolic processes that have been traditionally assumed to be restricted to other placental cell types are primarily driven by a layer of progenitor trophoblast cells, the cytotrophoblast, which have been ignored as significant contributors to placental metabolic function.
AD  - Oregon Health and Science University
AU  - Kolahi, Kevin
DA  - 2016-08-01
DO  - 10.6083/M4SX6C94
DO  - DOI
ED  - Thornburg, Kent
ED  - Advisor
ID  - 7871
KW  - Cell Differentiation
KW  - Placenta
KW  - Lipid Droplets
KW  - p38 Mitogen-Activated Protein Kinases
KW  - Oxygen Consumption
KW  - Fatty Acids
KW  - Fetus
KW  - Nutrients
KW  - Hormones
KW  - Pregnancy
L1  - https://digitalcollections.ohsu.edu/record/7871/files/kolahi.kevin.s.2016.pdf
L2  - https://digitalcollections.ohsu.edu/record/7871/files/kolahi.kevin.s.2016.pdf
L4  - https://digitalcollections.ohsu.edu/record/7871/files/kolahi.kevin.s.2016.pdf
LK  - https://digitalcollections.ohsu.edu/record/7871/files/kolahi.kevin.s.2016.pdf
N2  - The human placenta is the primary life-support organ for the developing fetus. It integrates a multi-organ system's functions but comprises only five major cell types. It is a highly metabolic organ, consuming 40% of the total oxygen used by the entire conceptus while accounting for only 20% of its total mass. This high metabolic activity supports the placenta’s extensive transport function, its manufacture of hormones, and the biochemical processing of nutrients. The precise functions of the cells within the placenta that underlie these processes remain poorly defined. This thesis reports that some of the metabolic processes that have been traditionally assumed to be restricted to other placental cell types are primarily driven by a layer of progenitor trophoblast cells, the cytotrophoblast, which have been ignored as significant contributors to placental metabolic function.
PB  - Oregon Health and Science University
PY  - 2016-08-01
T1  - Cytotrophoblast regulates lipid esterification and metabolic activity of the human term placenta
TI  - Cytotrophoblast regulates lipid esterification and metabolic activity of the human term placenta
UR  - https://digitalcollections.ohsu.edu/record/7871/files/kolahi.kevin.s.2016.pdf
Y1  - 2016-08-01
ER  -