000007880 001__ 7880
000007880 005__ 20250424233302.0
000007880 0247_ $$2DOI$$a10.6083/M4KP8147
000007880 037__ $$aETD
000007880 245__ $$aRegulation of ethanol seeking by the bed nucleus of the stria terminalis and the ventral tegmental area: evidence for a direct neural circuit
000007880 260__ $$bOregon Health and Science University
000007880 269__ $$a2016-03-01
000007880 336__ $$aDissertation
000007880 502__ $$bPh.D.
000007880 520__ $$aAlcohol use disorder is a chronic relapsing and remitting condition, where relapse  to  drinking  is  often  triggered  by  an  intense  desire  for  alcohol  (i.e., ethanol;  craving)  and  the  consequent  motivation  to  obtain  ethanol  (seeking). Environmental  stimuli  (cues)  associated  with  past  ethanol  use  are  believed  to strongly  contribute  to  relapse,  as  exposure  to  these  cues  can  trigger  intense feelings  of  craving  and  drive  ethanol  seeking.  Thus,  the  broad  goal  of  this dissertation  was  to  identify  the  neurocircuitry  underlying  cue-induced  ethanol-seeking  behavior,  as  indexed  through  an  ethanol-induced  conditioned  place preference  (CPP)  procedure.  Focus  was  placed  on  examining  two  distinct  brain regions  –  the  ventral  tegmental  area  (VTA)  and  the  bed  nucleus  of  the  stria terminalis  (BNST)  –  and  their  adjoining  (BNSTàVTA)  neural  circuit.  These regions  have  been  previously  shown  to  underlie  appetitive  behaviors  on  an individual and circuit level.
000007880 542__ $$fIn copyright - single owner
000007880 650__ $$aEthanol$$014406
000007880 650__ $$aDesigner Drugs$$028210
000007880 650__ $$aCraving$$040810
000007880 650__ $$aAppetitive Behavior$$015004
000007880 650__ $$aSeptal Nuclei$$025877
000007880 650__ $$aVentral Tegmental Area$$030064
000007880 650__ $$aBrain$$015788
000007880 650__ $$aAlcoholism$$014412
000007880 691__ $$aSchool of Medicine$$041369
000007880 692__ $$aDepartment of Behavioral Neuroscience$$041394
000007880 7001_ $$aPina, Melanie$$uOregon Health and Science University$$041354
000007880 7201_ $$aCunningham, Christopher$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000007880 8564_ $$9972ae2e0-77a3-4df5-8b0f-1404083edc1e$$s49158206$$uhttps://digitalcollections.ohsu.edu/record/7880/files/Pina.Melanie.2016.pdf$$ePublic$$201b50533103b98f6a1e54f36d2ce08d6$$31
000007880 905__ $$a/rest/prod/vt/15/0j/99/vt150j998
000007880 909CO $$ooai:digitalcollections.ohsu.edu:7880$$pstudent-work
000007880 980__ $$aTheses and Dissertations