000007906 001__ 7906
000007906 005__ 20250424233304.0
000007906 0247_ $$2DOI$$a10.6083/bc386j87q
000007906 037__ $$aETD
000007906 245__ $$aIterative graph perturbation to identify high impact nodes with application to genetic regulation of onset of puberty
000007906 260__ $$bOregon Health and Science University
000007906 269__ $$a2020-04-27
000007906 336__ $$aDissertation
000007906 502__ $$bPh.D.
000007906 502__ $$gComputer Science & Electrical Engineering (sunsetting)
000007906 520__ $$aComplex networks that connect hundreds or thousands of nodes together can function properly through the use of nodes interacting, affecting and regulating one another. Genetic networks underlying high-level hormonal changes are also believed to be complex and most of the time are not yet very well understood. There are also different networks with common genes that start to activate or deactivate at the same time, which also adds to the difficulty of the problem of understanding genetic networks. Therefore, finding genes transcriptionally active in a gene set that are responsible for a change in the human body is a key point in reaching the underlying network structure. Here, we present a new technique that searches for these nodes in a set of variables that connect to form a network. It is a stepwise greedy search that investigates the change in a chosen network when one node is taken out at a time.
000007906 542__ $$fIn copyright - single owner
000007906 650__ $$aGene Regulatory Networks$$037326
000007906 650__ $$aPuberty$$024878
000007906 650__ $$aHistone Code$$035185
000007906 650__ $$aHuman Body$$030935
000007906 650__ $$aRats$$036844
000007906 650__ $$aRNA-Seq$$013251
000007906 6531_ $$apartial correlation networks
000007906 691__ $$aSchool of Medicine$$041369
000007906 692__ $$aDepartment of Computer Science and Engineering$$041405
000007906 7001_ $$aSelcuk, Basak$$uOregon Health and Science University$$041354
000007906 7201_ $$aBedrick, Steven D.$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member
000007906 7201_ $$aLomniczi, Alejandro$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member
000007906 7201_ $$aHeeman, Peter A.$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member
000007906 7201_ $$aSonmez, Kemal$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000007906 8564_ $$9ea9e9bb9-391c-4f42-b1c4-1d6032e0d483$$s2404110$$uhttps://digitalcollections.ohsu.edu/record/7906/files/Selcuk.Basak.2020.pdf$$ePublic$$22d1593cda3b6a4e331c9915a55b3c431$$31
000007906 905__ $$a/rest/prod/bc/38/6j/87/bc386j87q
000007906 909CO $$ooai:digitalcollections.ohsu.edu:7906$$pstudent-work
000007906 980__ $$aTheses and Dissertations