@article{ETD,
      recid = {792},
      author = {Cleary, Donald},
      title = {Opioid-sensitive brainstem neurons separately modulate  pain and respiration},
      school = {Ph.D.},
      address = {2012},
      number = {ETD},
      abstract = {The rostral ventromedial medulla (RVM) regulates pain  through ON- and OFF-cell populations, which facilitate or  inhibit nociception. This thesis contrasts their roles in  acute versus chronic pain and explores interactions with  core functions such as respiration. In acute injury,  ON-cell activity drives hyperalgesia, but in chronic  inflammation, ON-cell inhibition exacerbates pain,  indicating distinct mechanisms. Respiratory monitoring  revealed that ON-cells modulate both pain and respiration,  while OFF-cells primarily mediate analgesia. Opioid effects  in the RVM confirmed separable pathways for analgesia and  respiratory depression. These findings advance  understanding of RVM physiology and suggest strategies for  developing non-respiratory-depressant analgesics.},
      url = {http://digitalcollections.ohsu.edu/record/792},
      doi = {https://doi.org/10.6083/M48G8HPB},
}