TY  - GEN
AB  - The rostral ventromedial medulla (RVM) regulates pain through ON- and OFF-cell populations, which facilitate or inhibit nociception. This thesis contrasts their roles in acute versus chronic pain and explores interactions with core functions such as respiration. In acute injury, ON-cell activity drives hyperalgesia, but in chronic inflammation, ON-cell inhibition exacerbates pain, indicating distinct mechanisms. Respiratory monitoring revealed that ON-cells modulate both pain and respiration, while OFF-cells primarily mediate analgesia. Opioid effects in the RVM confirmed separable pathways for analgesia and respiratory depression. These findings advance understanding of RVM physiology and suggest strategies for developing non-respiratory-depressant analgesics.
AD  - Oregon Health and Science University
AU  - Cleary, Donald
DA  - 2012
DO  - 10.6083/M48G8HPB
DO  - DOI
ED  - Heinricher, Mary
ED  - Mentor
ID  - 792
KW  - Analgesics, Opioid
KW  - Morphine
KW  - Medulla Oblongata
KW  - Respiration
KW  - Respiratory Insufficiency
KW  - Chronic Pain
L1  - https://digitalcollections.ohsu.edu/record/792/files/795_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/792/files/795_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/792/files/795_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/792/files/795_etd.pdf
N2  - The rostral ventromedial medulla (RVM) regulates pain through ON- and OFF-cell populations, which facilitate or inhibit nociception. This thesis contrasts their roles in acute versus chronic pain and explores interactions with core functions such as respiration. In acute injury, ON-cell activity drives hyperalgesia, but in chronic inflammation, ON-cell inhibition exacerbates pain, indicating distinct mechanisms. Respiratory monitoring revealed that ON-cells modulate both pain and respiration, while OFF-cells primarily mediate analgesia. Opioid effects in the RVM confirmed separable pathways for analgesia and respiratory depression. These findings advance understanding of RVM physiology and suggest strategies for developing non-respiratory-depressant analgesics.
PY  - 2012
T1  - Opioid-sensitive brainstem neurons separately modulate pain and respiration
TI  - Opioid-sensitive brainstem neurons separately modulate pain and respiration
UR  - https://digitalcollections.ohsu.edu/record/792/files/795_etd.pdf
Y1  - 2012
ER  -