000000792 001__ 792
000000792 005__ 20251218155428.0
000000792 0247_ $$2DOI$$a10.6083/M48G8HPB
000000792 037__ $$aETD
000000792 245__ $$aOpioid-sensitive brainstem neurons separately modulate pain and respiration
000000792 269__ $$a2012
000000792 336__ $$aDissertation
000000792 502__ $$bPh.D.
000000792 502__ $$gNeuroscience
000000792 520__ $$aThe rostral ventromedial medulla (RVM) regulates pain through ON- and OFF-cell populations, which facilitate or inhibit nociception. This thesis contrasts their roles in acute versus chronic pain and explores interactions with core functions such as respiration. In acute injury, ON-cell activity drives hyperalgesia, but in chronic inflammation, ON-cell inhibition exacerbates pain, indicating distinct mechanisms. Respiratory monitoring revealed that ON-cells modulate both pain and respiration, while OFF-cells primarily mediate analgesia. Opioid effects in the RVM confirmed separable pathways for analgesia and respiratory depression. These findings advance understanding of RVM physiology and suggest strategies for developing non-respiratory-depressant analgesics.
000000792 540__ $$fCC BY
000000792 542__ $$fIn copyright - single owner
000000792 650__ $$aAnalgesics, Opioid$$014660
000000792 650__ $$aMorphine$$022430
000000792 650__ $$aMedulla Oblongata$$021972
000000792 650__ $$aRespiration$$025348
000000792 650__ $$aRespiratory Insufficiency$$025360
000000792 650__ $$aChronic Pain$$039552
000000792 691__ $$aSchool of Medicine$$041369
000000792 692__ $$aVollum Institute$$041509
000000792 7001_ $$aCleary, Donald$$uOregon Health and Science University$$041354
000000792 7201_ $$aHeinricher, Mary$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000792 8564_ $$959c9efcf-5a97-4c10-8753-0afb56415a5b$$s3259522$$uhttps://digitalcollections.ohsu.edu/record/792/files/795_etd.pdf$$ePublic$$212e5df5d286e9e58564d7dfe25c0ec0c$$31
000000792 905__ $$a/rest/prod/ww/72/bb/56/ww72bb56b
000000792 909CO $$ooai:digitalcollections.ohsu.edu:792$$pstudent-work
000000792 980__ $$aTheses and Dissertations